Though widely used, the selective serotonin reuptake inhibitor (SSRI)
class of antidepressant (fluoxetine [Prozac], paroxetine [Paxil], escitalopram [Lexapro]) is relatively ineffective for headache.
Abortive treatment: This is designed to stop a headache once it has begun. Medications include ergotamine (Bellamine, Cafergot), acetaminophen-isometheptene-dichloralphenazone (Midrin), dihydroergotamine (D.H.E.