phenytoin hyperglycemia

The efficacy of oral hypoglycemic agents and insulin may be diminished by certain drugs, including thiazides and other diuretics, corticosteroids, estrogens, progestins, thyroid hormones, human growth hormone, phenothiazines, atypical antipsychotics, sympathomimetic amines, protease inhibitors, phenytoin, clozapine, megestrol, danazol, isoniazid, asparaginase, pegaspargase, diazoxide, temsirolimus, as well as pharmacologic dosages of nicotinic acid and adrenocorticotropic agents.

The efficacy of oral hypoglycemic agents and insulin may be diminished by certain drugs, including thiazides and other diuretics, corticosteroids, estrogens, progestins, thyroid hormones, human growth hormone, gonadotropin-releasing hormone agonists, phenothiazines, atypical antipsychotics, sympathomimetic amines, protease inhibitors, phenytoin, megestrol, danazol, isoniazid, asparaginase, pegaspargase, diazoxide, temsirolimus, sucralfate oral suspension, as well as pharmacologic dosages of nic

In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780] Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.

Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.

Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.

Is it possible for a person or child to display intermittant signs of hyperglycemia? My sever year old has always been sensative to sugar but when she is feeling good her sugar is normal but at other times she is nauseated and tired. Help!!

You should tell your doctor if you experience any of these symptoms while taking phenytoin, so that your blood level of phenytoin can be measured and your dose reduced if necessary. " Also, he has had a major surgery, and will need time to recover. However, any changes need to be reported to the doctor.

Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.

Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..

Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.

HIV has nothing to do with hyperglycemia nor does it cause hyperglycemia. You didn't have a risk of contracting HIV.

Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing.

You have posted on the type 2 forum, hyperglycemia, not type 1 aka juvenile diabetes. Prepare yourself to ask your doctor questions by using Google and search on 'hyperglycemia testing' and/or 'type 1 diabetes testing'. Also, call the doctor's office and ask if you should fast 8-10 hours prior. To add to allymarbles, an endocrinologist is a doctor who specializes in diabetes care and treatment. Most PCP's know only basic care - here take this pill, call me later.

There is much info on diabetics with hyperglycemia but very little on one that have hyperglycemia. I have a low sugar problem, that go to hypoglycemic symptoms, and doctors that only treat high sugar oroblems. Where can I find info on treatment of my type diabetic?

During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.

I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time? Thank you doctor once again for your immediate reply.

All of this has started within this year plus bad cholesterol is good good cholesterol is bad and Triglycerides are slightly elevated. Is there a relationship or link to Hyperthyroid and Hyperglycemia? Is all of this related? Should I take a watch and see? Is there others reasons my Thyhroid tests are coming back slightly out of range? What does Heterogeneous Thyroid mean? Is that normal?

Addition of other antiepileptic drugs like phenytoin,lamotrigene and sedatives will be helpful for controll of his night symptoms.

ve heard of that might help with the itch are trying the over the counter antihistamines or antihistamine hydroxyzine (Atarax), anticonvulsants (e.g. gabapentin, carbamazepine, phenytoin), antidepressants (e.g. amitriptyline, paroxetine, mirtazapine), and even Pregabelin (Lyrica)....

A few weeks ago I woke up with yellow crust on the corner of my lips and it went away in 2 days, and today I woke up and it's in the exact same spot again except a little more then before. It doesn't hurt or itch, it feels like my lips are very very dry. I don't smoke, I have grandmal seizures and my medication is phenytoin and kepra but I didn't read anywhere that would be a side effect so I'm worried this could be a STD or something.

Hyperglycemia can affect your brain negatively.

drugs like gabapentin, phenytoin are used for hemifacial spasm. Other options are botulinum injections and microvascular decompression surgery. Hope this helps. Take care.

Phenytoin hyperglycemia

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