Phenytoin history
Common Questions and Answers about Phenytoin history
dilantin
In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780]
Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm
Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
According to my Lippincott nursing drug book, Phenytoin (Dilantin) may decrease the effect of the steroid when used together. Therefore the steroid dosage would be adjusted according to what your physician prescribes. It does also state that prednisone is used cautiously in patients with history or seizures. There is nothing specific about those anticonvulsant med levels being affected. But I'm sure your physician will be monitoring you carefully.
Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
Hello AB, welcome to the medhelp forum. Phenytoin can cause certain side effects like dizziness and mental confusion. Some people may also manifest incoordinate movements. Weight gain is not a documented side effect. It could be related to your alcohol consumption or wrong dietary habits and lack of exercise. An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes.
During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
MS has been ruled out, as well as other demyleating (?sp) diseases. Her family history has diabetis, and yet the blood tests show no problems. The only thing that has showed up once was high on uric acid.
I know there are more than 100 causes. We want to find the reason. Can you think of any tests that we should consider for narrowing this down to what it is ?
I have zero history of cancer in my family. had needle biopsy on friday and am awaiting test results. also what causes this?
I totally forgot to tell you that he is on Phenytoin 100mg once daily. Can this be continued and taken for a long period of time?
Thank you doctor once again for your immediate reply.
The advice may not be completely correct for you as the doctor cannot examine you and does not know your complete medical history. Hence this reply to your post should only be considered as a guiding line and you must consult your doctor at the earliest for your medical problem.
Addition of other antiepileptic drugs like phenytoin,lamotrigene and sedatives will be helpful for controll of his night symptoms.
A few weeks ago I woke up with yellow crust on the corner of my lips and it went away in 2 days, and today I woke up and it's in the exact same spot again except a little more then before. It doesn't hurt or itch, it feels like my lips are very very dry. I don't smoke, I have grandmal seizures and my medication is phenytoin and kepra but I didn't read anywhere that would be a side effect so I'm worried this could be a STD or something.
drugs like gabapentin, phenytoin are used for hemifacial spasm. Other options are botulinum injections and microvascular decompression surgery. Hope this helps. Take care.
swollen inguinal lymph node.no fever or history of infection.currently taking oral antibiotic.what caused this and how can i prevent recurrence?
Hi everyone,
I'm new to this community.
My neurologist just informed me that Osteoporosis and shrinkage of the Cerebellum are very serious side effects for long term users of Dilantin. Does anyone know more about this?
I've been taking 500mg of Dilantin for over 30 years since I was a teenager, and now I'm terribly worried. Not one of the neurologists had mentioned anything about this over the years, and now at 46, I've learned that I may have severe osteoporosis.
consult a neurologist immediately, a balanced diet, foods high in potassium, calcium and magnesium, massages to relieve physical stress and fatigue, vitamin B complex rich foods,certain drugs like gabapentin, phenytoin,carbamazepine, botulinum toxin injections. Take care.
which is a new entity where patients with a long history of migraine have a severe migraine and then this can trigger a seizure." (I quote this from the Dr's letter) or the possibility of a very mild case of left temperal epilepsy.
The second eeg was okay but I have been on Phenytoin(Dilantin) since the episode. The Dr. was still unsure if it had been migralepsy or mild left temperal epilepsy.
After the 3rd eeg I think he is leaning to the mild left temperal epilepsy.
These are anti-epilepsy drugs such as valproate, carbamazepine, lamotrigine, phenytoin, gabapentin, and pregabalin; muscle relaxants such as clonazepam and baclofen; tricyclic antidepressants such as carbamazepine, amitriptyline, and nortriptyline. The other option is surgery: Stereotactic radiosurgery, cutting or destroying part of nerve or removing blood vessel or tumor pressing it. If there is a tumor or blood vessel causing the symptoms then medical treatment will not help.
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