Phenytoin blood levels

Common Questions and Answers about Phenytoin blood levels

dilantin

Combining fluoxetine or paroxetine with phenytoin can also lead to increased phenytoin side effects and reduce blood levels of paroxetine. You really need to discuss the potential drug interactions with your own doctor.
Please consult Neurologist for adjustment of doses of Phenytoin based on blood levels. bye and take care!
My doctor never mentioned that a huge amount of my ongoing health issues had anything to do with my AED The blood test is not an indication of phenytoin levels in your system, it measures what your body hasn't absorbed. It was only discovered I had the effects of Chronic Toxicity a few weeks ago My symptoms had been presenting themselves over the last decade, these were not recognised by my doctors. If you are on Phenytoin and you have any of the following Please, please get tested.
Use of many other prescription and non-prescription drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), lipid-lowering drugs, antibiotics, histamine receptor blockers (used to treat excess stomach acid production), antifungal agents, antidepressants, and hormones such as testosterone, can increase GGT levels. Smoking can also increase GGT. Gamma-glutamyl transferase (GGT) levels may be used to determine the cause of an elevated alkaline phosphatase (ALP).
elevated levels of ALT do not automatically mean that medical problems exist. Fluctuation of ALT levels is normal over the course of the day, and ALT levels can also increase in response to strenuous physical exercise.[1]" (http://www.aafp.org/afp/20050315/1105.html) "A thorough medical history and physical examination are the cornerstone of the evaluation of patients with mildly elevated liver transaminase levels.
Perform extremely intense physical exercise 4 to 5 times per week, eat organic according to the healthy diet principles of Weston A Price Foundation. Recent blood test show AST 55, ALT 79, total cholesterol 229 (LDL 110, HDL 111, TRI 42). Dr. concerned the high HDL could be related to a "nuerotoxic effect". I don't understand; I feel great--should I be concerned?
0 - 65 U/L Elevated GGT level can occur due to obesity. Causes GGT levels can be increased by alcohol phenytoin (Dilantin), an anti-seizure medication, and phenobarbitol, an antiseizure medication and sedative, and decreased by clofibrate, an anticholesterol drug, and birth control pills.
Treatment with phenytoin and amitriptyline may result in large amounts of phenytoin in your blood, which may cause more side effects of phenytoin than usual. Using phenytoin together with amitriptyline may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If you are using both medicines together, your doctor may change the dose or how often you use one or both of the medicines.
Is there a reliable calculation to work out the free or unbound phenytoin levels if you have low albumin. So, for example if a standard blood test showed Phenytoin 64.6umol/L and the albumin was 30g/L, can you predict accurately whether the unbound or free levels are in the therapeutic range? Would other factors like creatinine be considered?
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
Hi! Normally neither Singular nor Zertec will cause any change in the blood concentrations of the oral contraceptive pills. Usually drugs such as antibiotics, rifampicin (anti-tuberculosis drug), phenytoin (anticonvulsant), barbiturates, and carbamazepine (anticonvulsant) cause fluctuations in the levels of the oral contraceptive pills. However, please consult your gynecologist regarding this. Hope this helps. Take care!
Both of these medications can be very beneficial at certain blood levels, however if the blood levels are too high there can be problems. So the blood levels of digoxin and phenytoin are monitored in patients who are on these medications. If trazodone is given to people on either of these medications, extra caution needs to be taken in interpretation of the blood levels that are monitored.
An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes. Whereas if you are a chronic alcoholic, the phenytoin levels may be lower than expected and can cause seizures. I suggest you consult with your neurologist in this regard. Hope this information helps. Take care.
Similarly estrogen can also lead to increase in phenytoin blood levels and toxicity. It is best to consult your doctor and discuss about these possible interactions. Your doctor will suggest what is best for you and any alternative medicines if needed. I do hope it helps. Take care and regards!
Hi, Drugs which are used to control seizure may be phenytoin,valproate,carbamazepine or lamotrigene.Drug's concentration in blood should be in therapeutic range to control seizure fully.So do the blood levels of anti epileptic drugs which your son is using.This will guide us to make any changes in doses or addition of new drugs.
A therapeutic blood level of phenytoin 10-20 mcg/mL is considered as normal. Your blood levels are quite low. You may need an increase in dosage. It may be possible that these low drug levels are the cause of your break through seizure. It is best to consult a neurologist and get your doubts clarified. Do keep me posted. Best luck and regards!
SERTRALINE HYDROCHLORIDE (in Zoloft) may interact with PHENYTOIN (in Dilantin) Sertraline may block the breakdown of phenytoin by the liver. If this happens, blood levels of phenytoin could be increased and this could increase the risk of side effects. Side effects that may occur with the use of phenytoin include drowsiness, dizziness, headaches, and blurred vision.
His total calcium is in normal range but ionized calcium is low- 0.89 mmol/L. His Tg levels immediately after breast feed are in the range of 500 mg/dL which decline after 2-3 hours. His fasting Tg levels (12 hrs fasting) are about 160 mg/dL. Presently he is on maximum dose of phenytoin. What are the probable causes of seizures.
My name is Riaz, My wife delivered a baby the delivery was normal and the baby is healty but after 2 days of delivery she had epilepsy attack, first she complained severe headache and after a while vision loss and memory loss too. she never had a high blood pressure or hyper tension previously. MRI and Lumbar Puncture, Chest X-Ray and other blood related test has done and all reports are normal. my question is she can take eptoin being a lactating mother of a 20days baby??
Tumors affecting the gall bladder, liver or bile ducts could be responsible for elevated levels. An allergic reaction to the blood received during a transfusion can also cause the levels of bilirubin to rise in adults. Cirrhosis of the liver is another reason for elevated bilirubin levels. Acute hepatitis caused by Hepatitis A and Hepatitis B is another reason. Hemolysis - red blood cell destruction.
during this time he was told that the dilantin level in his blood was very low,thus the reason for the seizure. they have placed him on pills to raise it back up. But we are a lil confused. Is there another name for Dilantin? (I heard its Plasma). also is it something that everyone naturally has in their blood? And what causes the level to be low? Is there anything he can do naturally to keep it up besides taking pills? A diet change perhaps? Please help us understand better.
Anyway I have frantically been searching the net and came across B12 deficiency problems ( we are both veggies but eat good foods) it turns out in addiction to problems with being veggie, the phenytoin also knocks B12 for six. Eventually managed to get the doc to properly check her B12 levels (not just the ordinary blood test) this reveals her B12 levels are low at 120, so at last we have something real to look for.
As you know, depakote blood levels can be monitored. Increases in the blood level can cause side effects, and decreases in the blood levels may lead to seizures, if the blood level is not "therapeutic". A drop from 1200 mg a day to 750 mg a day can certainly change the blood levels of the medication. This could lead to seizures.
I was then lowered to 200mg which I could handle quite well. My levels were checked in Feb.08 and the levels were low at 29, my Dr. raised the dose to 250mg wich moved my levels to 55. which she said was good. In a short time of being on that I started to get the same side affects as on the 300mg. My Dr. told me to go back to the 200mg and she would have to talk to my Neurologist, I just had blood work done again and my phenytoin level come back at 2. How is that possible?
I believe that the benefits pf statins outweigh the risks and have altered my eating lifestyle so to nearly exclude carbohydrates. This has enabled me to continue statin regime while keeping my fasting blood glucose levels at acceptaptable unmedicated levels. My wife on the other hand continues to take Metformin while on the statin drug.
html In most patients maintained at a steady dosage, stable phenytoin serum levels are achieved. There may be wide interpatient variability in phenytoin serum levels with equivalent dosages. Patients with unusually low levels may be noncompliant or hypermetabolizers of phenytoin.
Rapid destruction of red blood cells in the blood, such as from sickle cell disease or an allergic reaction to blood received during a transfusion (called a transfusion reaction). Medicines that may increase bilirubin levels. This includes many antibiotics, some types of birth control pills, indomethacin (Indocin), phenytoin (Dilantin), diazepam (Valium), and flurazepam (Dalmane).
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels, that result from defects in insulin secretion, or action, or both. Diabetes mellitus, commonly referred to as diabetes (as it will be in this article) was first identified as a disease associated with "sweet urine," and excessive muscle loss in the ancient world. Elevated levels of blood glucose (hyperglycemia) lead to spillage of glucose into the urine, hence the term sweet urine.
Patients receiving a beta-blocker who require prolonged (greater than 1 week) concomitant therapy with an NSAID should have blood pressure monitored more closely following initiation, discontinuation, or change of dosage of the NSAID. The interaction is not expected to occur with low doses (e.g., low-dose aspirin) or intermittent short-term administration of NSAIDs.
An allergic reaction to the blood received during a transfusion can also cause the levels of bilirubin to rise in adults. Cirrhosis of the liver is another reason for elevated bilirubin levels. Acute hepatitis caused by Hepatitis A and Hepatitis B is another reason. Hemolysis - red blood cell destruction. Liver failure or any liver disease that worsens over a period of time.
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