Phenytoin blood levels
Common Questions and Answers about Phenytoin blood levels
dilantin
Hi, is he on some other drugs too because other drugs might decrease the level of phenytoin by enhancing its metabolism via induction of enzymes and can lead to drug drug interction. “Drugs which may decrease phenytoin levels include: carbamazepine, chronic alcohol abuse, reserpine, and sucralfate. Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin.
An occasional one or two drink may be fine but moderate or large amount can cause significant increases in blood levels of phenytoin due to induction of hepatic enzymes. Whereas if you are a chronic alcoholic, the phenytoin levels may be lower than expected and can cause seizures. I suggest you consult with your neurologist in this regard. Hope this information helps. Take care.
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
I was then lowered to 200mg which I could handle quite well. My levels were checked in Feb.08 and the levels were low at 29, my Dr. raised the dose to 250mg wich moved my levels to 55. which she said was good. In a short time of being on that I started to get the same side affects as on the 300mg. My Dr. told me to go back to the 200mg and she would have to talk to my Neurologist, I just had blood work done again and my phenytoin level come back at 2. How is that possible?
In a small study, phenytoin-induced seizures occurred most often in patients with serum phenytoin concentrations of 50 mcg/ml or higher.[393] Peripheral neuropathy, usually occurring weeks to months after drug initiation, has also been reported in patients receiving phenytoin. A single case report describes the onset of neuropathy within a few hours of drug administration.[9780]
Adverse GI effects of phenytoin therapy include nausea/vomiting, constipation, abdominal pain, and anorexia.
I believe that the benefits pf statins outweigh the risks and have altered my eating lifestyle so to nearly exclude carbohydrates. This has enabled me to continue statin regime while keeping my fasting blood glucose levels at acceptaptable unmedicated levels. My wife on the other hand continues to take Metformin while on the statin drug.
* Rapid destruction of red blood cells in the blood, such as from sickle cell disease or an allergic reaction to blood received during a transfusion (called a transfusion reaction).
* Medicines that may increase bilirubin levels. This includes many antibiotics, some types of birth control pills, indomethacin (Indocin), phenytoin (Dilantin), diazepam (Valium), and flurazepam (Dalmane).
Rapid destruction of red blood cells in the blood, such as from sickle cell disease or an allergic reaction to blood received during a transfusion (called a transfusion reaction).
Medicines that may increase bilirubin levels. This includes many antibiotics, some types of birth control pills, indomethacin (Indocin), phenytoin (Dilantin), diazepam (Valium), and flurazepam (Dalmane).
Pain and tingling could be due to neuropathy associated with vitamin B deficiency, abnormal thyroid status, altered calcium levels or other hormonal issues. Please get your blood vitamin B, calcium and thyroid levels done before considering other options for diagnosis.
Drugs like gabapentin, phenytoin, amitryptline etc are prescribed for neuropathic pain.
Hi there. Since your frequency of seizures has increased you need to have a fresh evaluation of your neurological function clinically, with a recent MRI brain and an EEG. The antiepileptic drugs need to be checked for a dosage modulation, assessment of adverse effects due to chronic usage over years like megaloblastic anemia, gingival hypertrophu and osteomalacia with phenytoin.
Take care.
An allergic reaction to the blood received during a transfusion can also cause the levels of bilirubin to rise in adults.
Cirrhosis of the liver is another reason for elevated bilirubin levels.
Acute hepatitis caused by Hepatitis A and Hepatitis B is another reason.
Hemolysis - red blood cell destruction.
Liver failure or any liver disease that worsens over a period of time.
I had impaired glucose tolerance due to hyperthyroidism. From the list below - thyrotoxicosis aka too much thyroid hormone.
Excerpt from Dr Kaslow's article General lab values..
black female 46 with exessive hair growth (chest, chin, upperlip been tested all came back normal not sure what test was done only know it was a hormone levels test no sonogram i have been shaving for years because cant find the source of the problem i have develop hyperpigmentation and holes and my face what can i do to get rid of it and is it wise to keep searching for a solution to my problem i have seen a (endrocrinologist, gyn) i have not seen a dermatologist
If a patient has drug eluding stent (DES) implant it is recommended that plavix (clopidogrel) be prescribed up to a year to help prevent blood clots with the implant.
If one has A-fib there is a risk that blood clots can occur as blood may pool due to the very fast beat.
Information regarding the use of the 2 anti-platelet together can present a problem and the source is MedinceNet.com.
Does prednisone effect dilantin and lamictal levels? I've been on dilantin and lamictal for over 5 years for seizures. I'm being tested for autoimmune hepatitis, I just had a liver biopsy. I don't want to take a chance on having a seizure.
Some infections, such as an infected gallbladder, or cholecystitis.
Some inherited diseases, such as Gilbert's syndrome, a condition that affects how the liver processes bilirubin. Although jaundice may occur in some people with Gilbert's syndrome, the condition is not harmful.
Diseases that cause liver damage, such as hepatitis, cirrhosis, or mononucleosis.
Diseases that cause blockage of the bile ducts, such as gallstones or cancer of the pancreas.
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