Phenytoin and hypoalbuminemia
Common Questions and Answers about Phenytoin and hypoalbuminemia
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I have hypothyroidism and my test were low and have developed hypoalbuminemia.
During those times I had not yet been diagnosed and was able to go back to life like normal, however after the diagnosis and being on phenytoin and switching to oxcarbazepine i am feeling awful. Dizzy, nauseated, moody, extremely tired, severe headaches that come and go. All i get from my Neurologist is these are side effects that will eventually go away. Because i never know when these symptoms will come on too strong I have missed a lot of days at work during my probation period.
This reaction is generally confined to the extremities but can affect the trunk and face and may be irreversible. Severe dermatologic reactions to phenytoin are infrequent. Some evidence, however, suggests that erythema multiforme is more likely in patients who undergo radiation therapy while receiving phenytoin.[22]
Lupus-like symptoms have been described for phenytoin. Whether phenytoin administration will exacerbate preexisting idiopathic systemic lupus erythematosus (SLE) is unclear.
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
t remember hitting them hard enough to cause this kind of bruise. I see my hepatologist for the big decision on when to treat and with what. I hope it's not still whether to treat, unless it is because someone else posted that another really good drug is getting FDA approval in August. Should I show them to him or call my regular doctor? Meanwhile, my fingernails are getting "wavy" and one is split down the middle.
With all the results you have, I hate to ask, but could you just post your TSH Free T3 and Free T4 and include the reference ranges provided for each? Ranges vary fron lab to lab, that is why they are needed to see how you are with your thyroid, as far as Testosterone is concerned, it normally does not affect the thyroid levels.
Moban® brand of molindone hydrochloride contains calcium ions which interfere with the absorption of phenytoin. Ingestion times of phenytoin and antacid preparations containing calcium should be staggered in patients with low serum phenytoin levels to prevent absorption problems”. Taken from http://www.rxlist.com/cgi/generic/phenyt_od.htm
Our population is divided into 4 type of metabolizers ranging from rapid to slow metabolizers depending upon the speed of elimination of drug from body.
Thank you for your question, you are relatively fine with Phenytoin and the seizure episodes in a form of lack of speech are the residue of a generalized type seizure. I don’t have a full description of your consciousness during the lack of speech episodes to decide whether this start is a partial epilepsy which can continue in a generalized or it is a generalized one from the first moment..
If you are pregnant your doctor may gradually decrease the dose and stop it and may prescribe an alternative anti seizure medicine which is safe during pregnancy. Sudden withdrawal of antiseizure medication may precipitate seizures in a pregnant woman which can be dangerous for the fetus. Medicines are prescribed during pregnancy only if the benefits outweigh the risks. Your doctor may prescribe you high dose folic acid 4 mg to prevent spinal cord deformities. I sincerely hope it helps.
I have been on Coumadin for 18 years due to Lupus Anticoagulant (Antiphospholipid Syndrome) and several DVTs. In 2005 had MI with occlusion of the LAD artery and had drug stent inserted and I am still on plavix. My doc has debated when to take me off the Plavix safely....what are the recent studies about this dilemma? thanks so much!
Subsequent to discharge on 10 July, she was put on phenytoin 200 mg od. She broke out with fever again on 15 July and the fever lasted for about 4 days with daily temperature peaking in the afternoon (max 101 F). The face and body were covered with rash similar to measles which resolved by 20 July. Could she have had measles at her age? Why did she have convulsions? Could anyone throw any light on the episode.
A few weeks ago I woke up with yellow crust on the corner of my lips and it went away in 2 days, and today I woke up and it's in the exact same spot again except a little more then before. It doesn't hurt or itch, it feels like my lips are very very dry. I don't smoke, I have grandmal seizures and my medication is phenytoin and kepra but I didn't read anywhere that would be a side effect so I'm worried this could be a STD or something.
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