m allergic to Murpirocin, neosporin, bacitracin, clindamycin, metronidazole all topicals and had a syncope from a tetracycline type drug. My brother is anaphylaxic
to penicillin. It sounds like you can tolerate
Mupirocin but the topical isn't enough for your tissue infection. Celluitis can be pretty deep in the tissue so if it isn't working either the bacteria are resistant to it or it isn't penetrating the tissue well enough.