Losartan arb
Common Questions and Answers about Losartan arb
cozaar
s that have been dealing with my blood pressure running 140/ 90 for a while my doctor put me on Losartan HCTZ 50- 12.5 and my pressure. After my 6 months check up my pressure was still the same so he increased my Losartan to 100-12.5 and a few weeks after I would get readings of 130 /80 sometimes and others I would get 129/78.
By the way, Pat, regardless of whether you have Marfan Syndrome or not, you might Google "losartan" and "Marfan Syndrome" to read articles on this topic. I don't think losartan is the best ARB, but it's the one being used in the current studies. All ARBs seem to work, some better than others. Efficacy is usually dose-dependent.
Or is the Cozaar good enough? (Some places even suggest taking an ACE along with an ARB...is that a good idea?)
Blood Thinners: Should I be taking one? (And is low-dose aspirin safe? There seems to be conflicting thoughts on this for people with CHF.)
Supplements: Should I be taking any?
What about statins? Vasodilators? Digoxin?
I apologize for the long post. I appreciate your time & help.
My internist has suggested switching from lisinopril to losartan since a New England Journal of Medicine article (June 26, 2008) reported better management of root diameter with an ARB. My cardiologist is less willing to make the switch since my root diameter has been stable at 3.8 cm for a few years. I'd appreciate your thoughts on the benefits of switching to losartan.
I have been telling people on these boards for a long time to investigate angiotensin receptor-blocker (ARB) (any ARB except losartan is preferable) or ACE-inhibitor (ACE-i) (perindopril is the only one I know of that really works) therapy with a cardiologist at a major medical center/university who is UP TO DATE on the latest research.
These are the ACE drugs and the ARB drugs. The best,in my opinion is the ARB drug Losartan, invented 1990, approved 1995, sold about 2000 and out of patent 2010 (therefore inexpensive). This drug blocks angiotensin varients from attach to the cells walls of the vascular system and cause vasoconstriction. Dose is generally from 25mg to 100 mg a day. Over 100 mg doesn't help much more. They prescribe once a day, but you can break up the dose into two pills a day.
Hi, you might know that there is commonly a dry cough from the class of hypertension drugs called ACE Inhibitors. A cough from losartan (which is not an ACEI, but an ARB class) is much less common; but that still seems to be the best suspect. The 'A' in each class stands for angiotensin, so the way that they work is related.
The metoprolol (from the beta blocker class) is also a possible cause, but less likely.
and 145 lbs and still not done growing. His Dr. is communicating with Dr. Dietz at Johns Hopkins in regards to Losartan. Does anyone have any input on this drug with a teen? Or does anyone have a child in this type of situation? Any input would be comforting to me.
Unfortunately the HCV was not eliminated and when I ran across an article that indicated that losartan(Cozaar) a blood pressure medicine may reduce or eliminate fibrosis I asked my doctor to change on of my blood pressure medicines to it which he did, coincidently on that visit he detected some fibrosis by feeling the stiffness of my liver.
The hepatic stellate cells (HSCs) are activated into myofibroblast-like cells that produce the fibrosis by angiotensin II.
The ARB (angiotensin receptor blocker) with recent research has shown that one ARB drug, Losartan, can prevent aortic growth. I don't know of any trial studies that support, but your doctor may have more information on the subject, and it appears to help those with aorta root aneursyms.
Dizziness is not a recognized symptom of an aorta enlargement. Thanks for your response. Take care.
That is an excellent question. Leg cramps are often caused by what is called intermittant claudication, which is related to blood circulation. A pacemaker may limit blood circulation under certain circumstances. Unlikely, but not impossible. Speak to your cardiologist about this. They question is not that silly. He need a color dopplar of his legs to evaluate circulatory status, to keep well-hydrated, and excercise regularly, walking as much as possible.
Losartan is not a beta blocker. Instead it is an ARB. By blocking the action of angiotensin, losartan relaxes muscle cells and dilates blood vessels, reducing blood pressure. It can cause nasal congestion and persistent cough,
Since you have both the cough and leg swelling, you should ask to try another bp medication. There are other types.
Bingo. Avapro is an ARB like losartan. I STRONGLY suspect that the avapro shrunk your aortic root. I would encourage you to stay on this drug and if your cardiologist for some reason ever wants to take you off it, to make sure that he or she is aware of all the studies discussing ARB therapy and aortic root shrinkage. Please educate yourself on this - exceptionally important. I'm happy to answer any questions if you send me a private message.
You should also be aware of angiotensin receptor blocker (ARB) therapy. Click on my screenname and read previous posts on the topic, or Google the terms "losartan" and "Marfan." There is evidence that these drugs can halt or reverse aortic dilatation in MFS patients, perhaps precluding the need for surgery.
as a starting point for your research, realizing that losartan is probably the weakest ARB out there and that others are much stronger. I realize Marfan has been ruled out but the mechanism for action in these drugs appears to be the same for other connective tissue diseases.
After reading up on the research, contact the clinic of Dr. Hal Dietz at Johns Hopkins for an evaluation or for a recommendation for a more knowledgeable pediatric cardiologist in your area.
First, read up on angiotensin receptor blockers (ARB). I have written many posts about them. Click on my screenname and find my old posts. These drugs have been shown to reduce/halt aortic enlargement in many people.
Second, how big is your aorta, and where on the aorta was the measurement taken?
Your son should at least be on a beta blocker (which nearly every cardiologist knows about and is the current standard of treatment for connective tissue problems and dilated aortas), and if your cardiologist keeps up-to-date at all with current research, s/he would be considering your son for losartan or another ARB drug.
Most doctors are ignorant about this - even cardiologists.
Listen, you need to educate yourself on a class of drugs called angiotensin receptor blockers (ARB for short). They include drugs such as losartan, irbesartan, valsartan, telmisartan, etc. (anything ending in "-sartan"). The most cutting-edge studies coming out of Johns Hopkins have shown that these drugs HALT and/or REVERSE aortic root dilatation. It appears that a maximal dose is required.
Although you may or may not have Marfan syndrome, I strongly encourage you to visit www.
For someone of your aortic size, I would take it easy. Try the ARB approach with a max or ultra-max high dosage (as long as your doctor lets you) and see if that reduces aortic size and aortic flexibility (the "pulse pressure" is one way to estimate the flexibility - Google it). If so, then perhaps you can talk to your doctor about athletics. I assume goalies don't work nearly as hard as the other positions do, so perhaps it's not out of the question.
“We are very encouraged by these promising results from the ongoing Phase II study of ARB-1467 which, as expected, showed a greater reduction in HBsAg with three monthly doses of 0.4 mg/kg ARB-1467 than was seen with 0.2 mg/kg ARB-1467,” said Dr. Mark J. Murray, Arbutus’ President and CEO. “We are excited by the possibility for yet greater HBsAg reductions with additional doses.
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Recent Highlights and Developments
Ongoing Phase II study of ARB-1467 evaluating two doses of ARB-1467 (0.2 mg/kg and 0.4 mg/kg) in HBV infected patients.
Preclinical combination data presented at the 5th Antiviral Drugs Research and Development Conference showing additive anti-HBV activity when combining AB-423 (core protein/capsid assembly inhibitor) with entecavir or interferon.
You will also find excellent info about familial aortic disease on www.bicuspidfoundation.com.
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