Do not take Imitrex if you have underlying cardiovascular diseases, if you have uncontrolled hypertension, if you are taking MAO-A antidepressants or and do not take
Imitrex if you have severe hepatic impairment.
It is not suggested that you take
Imitrex at the same time as any other prescription acute migraine medication such as another triptan or any ergot-type medication (ergot medications were the first line of acute therapy in migraine headache prior to the invention of triptans).