Amlodipine mechanism of action

Common Questions and Answers about Amlodipine mechanism of action

norvasc

Norvasc (amlodipine) is not contraindicated with beta blockers but other calcium channel blockers such as Diltizem or verapamil have a relative contraindication. It has to do with the mechanism of action of these meds. Amlodipine affects a different calcium channel then the other two.
A recent paper studied the effect of most FDA approved drugs on the inhibition of NTCP, the now known entry receptor for HBV. Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg.
Amlodipine, Benazepril, Bumetanide, Carvedilol, Digoxin, Dipyridamole, Doxazosin, Enalapril, Hydralazine, Lisinopril, Losartan, Metoprolol and Hydrochlorothiazide, Nifedipine, Procardia XL, Propafenone, Ramipril, Sotalol and Verapamil. At any rate, he should discuss this with his doctor.
I have had good results with Lyrica (yes, another calcium channel blocker) and Keppra. Keppra's methods of action appears to be that the drug interferes with the mechanism for reducing the synaptic gap, and with the synaptic gap too large, the transmitting nerve ending doesn't release pain neurotransmitters. All nerve signals travel via a combination of electrical and chemical pathways, so Keppra blocks pain by interrupting the chemical pathway.
i guess it is better to try Myrcludex in the immune clearance phase at this point after your light in to the darkness of Myrcludex way of action i do prefer replicor drug, the only thing i fear is a different effect on hbeag negative since the hbeag guy on the huma trial had no response, do you have any data about this? i guess hbsag might be produced in different sites on hbeag negative and i guess it is better to combo also on rep9ac to prevent hbsag mutants...
I had tonsilectomy 2 weeks prior the click started and I feel that this click is the after cause of the surgery. Of course ENT will say that everything is fine, because he is the one that did the surgery... I keep touching my wind tunnel and pushing it with my fingers to the right, something clicks, then after I swallow next few times there is no click and then it comes back again. Very tired of this clicking sound... Don't know if it ever will go away.
I have been having symptoms of dizziness, head pain, shakiness and a spaced out kind of foggy feeling like i am watching my life from the outside - all day every day. There are some times for a couple of hours during the day that the symptoms may lift and give me a few moments to live- but not much. I have been to about 30 doctors- including ENT's allergists, neurologists, chiropracters, opthamologists. psychologists, dentists and everything else u can think of.
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