I am a 27 year
woman and I have had chronic autoimmune hives for
years now. Like others, the first incident was a reaction of hives & angiodema to ibuprofin, which I had been taking for years. Now, I get them all the time, for no reason. I've been on hydroxizine, xyzal, fexofenidine, doxepin, claritan, ranitidine, and of course, the dreaded prednisone. I have found that all anti-histhamines so far have little to no effect.