Treatment with Flavocoxid or ETV or with drugs combination started 3 hours after transfection and was renewed every other day for 5 days. Total HBV replicative intermediates, viral transcripts and cccDNA levels were evaluated in untreated and treated HepG2 cells by quantitative real-time PCR, Southern and Northern blots experiments. To analyse the epigenetic modulation of HBV cccDNA the cccDNA-ChIP assay was applied to untreated and treated cells.
I am eating zidovudine and lamivudine !and I am a smoker so i just wanna know smoke will influence medicine or not?
I ate lamivudine and zidovudine at 22 hours late after the behavior.Does it will work well?
I was given Epivir, Viread and Zidovudine.
Depakote can also increase levels of other drugs in the body, including diazepam (Valium), ethosuximide (Zarontin), warfarin (Coumadin), and zidovudine (Retrovir). Talk to your doctor before taking these medicines with Depakote.
After investigation, the doctor prescribed PEP for 28 days. The tablet name is DUOVIR (Lamivudine 150MG/Zidovudine 300 mg). The doctor told to take "half tablet" in the morning and "1 full tablet" in the night.
When I read the leaflet inside the tablet, it is written that it should be given to adults or children over 12 years of age. It is mentioned that it should not be given to children below 12 years of age.
My son is 7 years old. I don't know what to do?
Since that time, he is receiving HAART with lamivudine-zidovudine-efavirenz twice daily, but he told me that there are some days ( at maximun 3) that he does not take the pills, but most days of the month he is adhering to the treatment. His current viral load is 39,000 copies/ml.
When I realized of him diagnosis, I went to a doctor who gave me profilaxis about 18 hours post-exposure with lamivudine-zidovudine.
my regimen was Zidovudine+Lamivudine+Aluvia, i mean, i missed one dose of Zidovudine+Lamivudine+Aluvia...you mean I should add one dose more on the end?
1 - would PEP be effective even if the source has a high viral load?
2 - After the 28 days, can I drink alcohol?
Thank you very much in advance, I am quite distressed about it.
No Risk in a "Prick" alone. HIV is transmitted via INJECTION from needles not pricks. You should have still reported this and followed the hospital rules for this type of event.
s ability to readily detoxify the reactive intermediates or easily repair the resulting damage. Disturbance in this normal redox state can cause toxic effects through the production of peroxides and free radicals that damage all components of cells, including protiens, lipids and DNA. Uric Acid is increased by diet of high fructose intake (corn syrup) and purines found in high amounts or animal food products. Check your diets, my husband drank alot of Mountain Dew and likes to hunt.
I performed oral sex on a guy that I later found out has HIV. I certainly swallowed a bit of his cum during the oral sex and the next day discovered he is taking Atripla (medicine for hiv treatment which is said to reduce the viral load to undectable in most cases).
I freaked out and bought lamivudine/zidovudine 150/300mg as a preventive measure (I'm travelling so that was my option). What are my risks? Am I overreacting?
Dear Doctor
I am straight male 28 years old. On may 20, I had one possible exposure with involve with broken condom with KTV girl in Cambodia. I asked the girl about her HIV status she replied to me, "I want you feel scary for couple months". I told my friend about incident then he went to ask the girl to test and it came back negative. 12 hours after incident I was prescribed PEP for a month.
sir,
i went to prostitute and used condom while doing sex with her. at that time on my right hand's middle finger, there is a 24 hour old small abrasion of 1cmx1cm which was not bleed, and i removed the condom with my right hand. then i feared that the hiv virus may enter through the abrasion. i don't know whether she had hiv or not. at the 14th hour of that exposure i started PEP with zidovudine and lamivudine. on 15th day of PEP course, i missed two doses and then completed in 28 days.
combivir is adeqaute depending on your risk, most doctors prescribe this, it is the standard regimen, it consists of 2 drugs, lamivudine and zidovudine. PEp is a combination of 2 or 3 drugs which can reduce the chances of hiv infection by up to 85%. If you want more u can get more, but in most low risk encounters like yours combivir works just fine.
I went to a clinic and startednPEP (Zidovudine, Lamidovudine and Epivir), the nausea and vomiting has been really bad, also some diarrhea, but i am dealing with it. But today on day 17 of the Treatment I started running a low temperature, 37.5C / 99.6F, also i feel some enlarge nodes, that might have been there before, but not sure.
I am quite scared as the fever started sudden and with no other symptoms of illness.
Thanks JB.
to mike1105: thanks.
You say it's a bit tricky to get the "intermediates" right. Since posting I located an old friend out of town(who is a D.D. but no longer practicing) and he told me over the phone several things: 1) he never heard of "intermediates" for the type of denture replacement I described. I had a functioning set of dentures which were there to be used for control prior to the surgery - they were not.
It is probable that these cells could support viral replication because hepatitis B virus DNA replicative intermediates, viral transcripts and HBsAg and HBcAg proteins were detected in most. These findings may be relevant to the initiation of extrahepatic syndromes associated with chronic hepatitis B virus infection such as vasculitis, glomerulonephropathy, neuropathy and dermatitis.
Similarly, extensive analyses of intrahepatic woodchuck hepatitis virus (WHV) and duck hepatitis B virus (DHBV) DNA intermediates under nucleoside analog therapy clearly demonstrated that cccDNA become the predominant form of viral DNA replication intermediates upon long-term suppression of viral DNA replication40 and 41. These findings strongly suggest that cccDNA is the most stable HBV replication intermediate and elimination of cccDNA is the key to cure HBV infection.
Alan McLachlan at the University of Illinois-Chicago, dramatic reductions in viral transcripts, viral replicative DNA intermediates, and intracellular HBV core antigen were observed in the liver after two weekly doses.
m a 26 yr old male and had a supposed exposure to HIV (insertive vaginal sex) on January 4, 2008. Following which I had started with PEP, Zidovudine 300 mg + Lamivudine 150 mg, for 6 weeks. The PEP started within 36 - 48 hours of exposure. Since, I couldn't afford to the expensive PCR tests, I decided to wait for 3 months after completion of PEP to go for an ELISA test. Today, June 17, 2008 I had given the sample for testing and will have the results by tomorrow.
I saw a dr and he put me on a regimen of pep due to the risk of hiv in the phillipino sex worker population. This regimens is lamivudine/zidovudine. After reading through these forums I am concerned that I am using pep when it isn't needed. I have been on this for two weeks so far. Should I stop or continue the pep? Was pep warranted? Could the reasons listed make me a higher risk. Anyone's help is appreciated.
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