Hi -
I had my first OB of HSV 2 almost exactly a year ago (diagnosed by culture). I had a CRIPPLING first OB, followed by repeated OBs for a couple months, even while I was taking acyclovir. I had horrible PHN, mostly in my lower back, tailbone, and legs. The acyclovir caused severe bruising on my trunk and legs, and wasn't controlling the OBs. I switched to Valtrex 500/day about 6 months ago, and since then, have been completely OB free.