Valacyclovir prodrug
Common Questions and Answers about Valacyclovir prodrug
valtrex
Valtrex is an acyclovir prodrug. Greatly simplified - you swallow valtrex and your body converts it into acyclovir inside the body. You get more active acyclovir available to kick a little herpes butt by doing it this way. That's why you take valtrex less often. We don't have studies to confirm that acyclovir reduces transmission the same amount as valtrex does but we assume it does.
http://racoon.com/herpes/v_a_compare.
yes and no. Valtrex is an acyclovir prodrug. what that means if you swallow valtrex and your body changes it into acyclovir inside your body. Because of that unique delivery method, you get more active acyclovir available to fight the herpes virus when it's active so you take it less often. The main difference in the two of them is convenience and of course price.
ContraVir reports data shows CMX157 more potent against HBV than Gilead Viread
ContraVir Pharmaceuticals (CTRV) announced preliminary data dramatizing the unique properties of CMX157, the company's highly potent lipid prodrug of the successful antiviral drug tenofovir, or TFV. CMX157 was shown to be 60-fold more active than tenofovir against the hepatitis B virus, or HBV, based on in vitro studies.
I talk valacyclovir for herpes out breaks I have a high dosage one for when I get them it doesn't harm the baby.
Though this is my first pregnancy and I'm 7 weeks.
They told me once I get closer to my due date to take them daily so there is no break out.
t want it there so I started to take Valacyclovir it would keep breaking out every month or so I went on a daily maintenance of 500mg a day. When ever I would miss a pill I start feeling the sensation which I felt when I was going to get an outbreak. I would keep taking it for 5 years. I wanted to stop taking it so I had read some Medical Article's online that Valtrex can rebound.
I'm not sure that I understand your response.
1. I think that you meant to say that "experience tells us that when people ?quit? taking the valacyclovir, they sometimes do have an outbreak soon after that." This is my concern, that the valacyclovir takes over and that the body's immune response is less engaged in fighting the infection. Do you see what I mean?
2.
Short Answer:
This depends on your metabolism, but in general it will stay in your system for 24-36 hours with a *low dose* (ie. no more than 30mg of codein). However with larger doses, it will be in your system for 48-72 hours depending on how high your dosage was.
Long Answer:
The half-life of codeine is 2.9 hours. This means that in 2.9 hours, only half the amount of codeine is remaining. In another 2.9 hours another half of that, and so on.
As such I contacted my doctor and was prescribed valacyclovir hcl which I took (2 1 gram tablets twice daily). The cold sore remained small and eventually went away. After this I went 1-2 days without taking any Lysine or valacyclovir and on the second day I noticed the cold sore coming back again and now appears to have come back and crusted over. I did not think the new cold sore was actually one but then it crusted over.
And although recurrent outbreaks can occur while taking valacyclovir, they are rare -- and monthly is unheard of. It is possible your HSV has become resistant to the drug, but that's quite rare as well.
As for valacyclovir side effects, you needn't worry.
I was diagnosed with Herpes 33 years ago and have been using 1000 mg Valacyclovir a day for the past 4 years and have been free of outbreaks until a few weeks ago when I lost my job and became quite stressed.
I was able to take one extra tablet of 500 mg which stopped the outbreak from turning into blisters, but I am concerned if this medication is not working for me anymore.
I also wonder if Valacyclovir is the same as Valtrex or if Valtrex is stronger?
I appreciate your help.
I'm on daily 1 gram valacyclovir for suppressive therapy. I can feel a new outbreak coming. Would it help if a take the valacyclovir twice daily for a couple of days to help with the OB?
What are the contraindications of taking penicillin and valacyclovir during the same cycle ? Can they both be taken on the same day ?
I got infected with genital herpes about 5 months ago, from unprotected oral sex from a striper.... I took valacyclovir 1 g twice a day within 24 hours of the initial episode, and kept taking it until I got better, which took a while (a month almost)....
My symptoms (ulcers, itchiness and pain/discomfort) have been recurrent and very persistant since. I think I have had symptoms 3-4 out of every 5 days since day one.
I have read that Valtrex and Valacyclovir can be used for the suppression of herpes , does that hold true for Valcivir also,, isn't Valacyclovir the generic of Valciver ,, if yes what is the usual dosage for the suppression of the virus?
I had a standard HIV test done on the first day of symptoms (about a week after my last sexual exposure) and that test came back negative. Doc now has me on valacyclovir because he thinks i have oral herpes. The valacyclovir has taken much of my fever away. And the nystatin and valacyclovir have together mostly cleared up my tongue sores and blisters. But I feel like without the valacyclovir, i'd be very very sick. Also my lymph node on the right side of my groin is still quite swollen.
thank you so much for giving me these tips. I'm taking Valacyclovir following my doctor's prescription. I maybe try the topical cream you suggested to qucikly ease leaking fluid.
My question is, can Valacyclovir be taken as a preventative measure if I take it a few days in advance of the big event? If so, what dosage? Thanks.
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Would you double the valacyclovir dosage or at least up it? What about for long-term suppressive therapy? If someone could in particular elucidate how valacyclovir works and WHY it would be important/ unimportant to adjust that dosage based on wanting to suppress both conditions, you would have my eternal thanks.
My dr prescribed me with 30 1g of valacyclovir with no instructions on taking them. I took 1g of valacyclovir every day for 30 days. My last day taking valacyclovir was 02-28-18. I took a igG herpeselect blood on 4-3-18 and it was negative. I was told that the antivirals affected my test and i would have to be off of them for 12 weeks. So i tested again for hsv 1 and 2 on 05-24-18 exactly 12 weeks off of antivirals and it was negative.
valtrex is an acyclovir prodrug. when you swallow it, during digestion the body turns it into acyclovir. because of this unique delivery method, you get more active acyclovir available in the body so you don't have to take it as often.
Even though valtrex is an acyclovir prodrug, some folks just do better on the acyclovir than they do the valtrex. My guess would be because you get less active acyclovir in your body with plain ole acyclovir than you do valtrex but we have no studies to back this assumption.
So, you have, like a lot of people, herpes simplex 1. It IS contagious so be careful of that so you don't spread it to others. Don't pick the sores off. Take the medicine and if you feel a tingle like another cold sore is coming, use the valacyclovir. You may have angiokeratoma of Fordyce which normally goes away if left alone.
tenofovir disoproxil fumarate) is a prodrug of tenofovir. The 'disoproxil' is a side chain attached to the active component 'tenofovir'. Inside our body, this side chain gets cleaved off by an enzyme to release the active tenofovir. AGX-1009 has a different side chain attached to the active component 'tenofovir'. It may show higher potency and/or lower toxicity compared to Viread because of this different side chain (At least that's what Agenix is hoping for).
I believe (though I could be wrong) valacyclovir is the only drug that is approved by the FDA for suppressive therapy, because it's the only drug that has had an FDA registered clinical trial performed for this purpose. However, it is well documented that valtrex and acyclovir perform very similarly. Valtrex is actually converted into acyclovir by the liver, so essentially, the two drugs act the same way in the body to suppress the virus.
Clinically symptomatic HSV-2 infection developed in 4 of 743 susceptible partners who were given valacyclovir, as compared with 16 of 741 who were given placebo (hazard ratio, 0.25; 95 percent confidence interval, 0.08 to 0.75; P=0.008). Overall, acquisition of HSV-2 was observed in 14 of the susceptible partners who received valacyclovir (1.9 percent), as compared with 27 (3.6 percent) who received placebo (hazard ratio, 0.52; 95 percent confidence interval, 0.27 to 0.99; P=0.04).
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