If both the infected and uninfected members of a couple consistently take any of the anti-HSV drugs (acyclovir,
valacyclovir, famciclovir), I cannot imagine transmission taking place.
You are wrong about suppressive therapy and blood test results. If someone catches HSV-2, the blood test becomes positive. If it remains negative, no infection occurred.
For suppressive therapy to prevent transmission, I normally rely on valacylcovir 1.0 g once daily.