tysabri ms exacerbation

Wow, this sounds so much like my new neuro (not by my choice--last one left for very high-profile job). This one says that my major flare symptoms are only a pseudo-exacerbation because MRIs have been stable and symptoms are not exactly new, just much worse variations on an old theme. I have never before heard this version of pseudo-exacerbation versus genuine exacerbation. All I know is 'this thing' has been going on for 3 months now with no end in sight.

Before Tysabri, she was taking Rebif, and her MRI was showing advance in lesions. I think Tysabri has helped to slow down her MS, and if you ask my sister whether or not Tysabri has made a difference, she would most certainly say it had. For those of us with MS that have a more aggressive disease course, it's nice to still have an option available for us.

Here are some of the drugs that are used to treat MS. All of them have some problems and are not completely effective. You can learn more about these on the WebMD site. Interferon Drugs for Multiple Sclerosis (Avonex, Betaseron, Rebif)Interferon beta drugs help control the immune system, which helps control MS. Glatiramer Glatiramer helps prevent the body's immune system from attacking nerve fibers. Novantrone Novantrone slows disability and reduces the relapse rate.

I have read on here by several members, that they have not considered Tysabri or Gilenya because their MS is not that aggressive. What does that mean? I was dx Jan 2010, MRI showed approximately 10 lesions, I had a real hard time accepting my dx....I really wasn't sure I had MS, so I refused a DMD. Then in Oct 2010, I had a new MRI that showed an additional 5 lesions. My Neuro said that we needed to get aggressive and he suggested Tysabri and/or Gilenya.

Hi and welcome. I can't say anything about Tysabri side effects as I've never been on Ty, but quite a lot of others here have been, and some of these will be able to comment on this through their experiences. I can say, though, that the bumps/rash are very likely to be a reaction to something or other, and in themselves are not an MS symptom. Now as to why you're having more MS problems, I'd say it's because this is a genuine relapse.

Has anyone been recently been diagnosed with MS and awaiting Tysabri treatment? And been suggested that they may have Bipolar disorder due to several mood swings?

He was cool but it was obvious he was strictly interested in how the Tysabri was effecting my MS and not so much about me overall. He was still nice enough but not quite the same as the female. I got a severe cold after my treatment this last December and it went away then cam back in full force the day I had my treatment 4 weeks later. The specialist actually wrote a note to my GP that I am complaining of a chronic cough...I don't believe that is the same thing.

There are many anecdotal reports from patients of either a vaccine or an illness causing an MS exacerbation, but no real good scientific evidence to support these claims. As with everything in medicine, the pros and cons have to be weighed. If you are at high risk for complications from the flu, you should definitely get the flu vaccine. If you are young and otherwise healthy, I personally would probably still get the flu vaccine, but some people with MS would choose not to.

I went to UCSF Fri to be checked out before I can continue my Tysabri treatments. I had one treatment and because of a worsening of old sx's the specialists had to "check me out" before approving going forward with treatment. I saw an assistant and not the main Dr (pretty sure that is how it always works at the medical centers) and she feels that a UTI is causing me to be in a pseudo flare.

Thanks. I will do that. I saw three neurosurgeons about more minor versions of these and other symptoms in the months before I finally figured out myself that I probably had MS which this neurologist confirmed. He is generally very responsive....enough so that he switched me from Avonex to Tysabri after 18 months and rounds of steroids.

But, I cannot imagine what else this could be besides the beginning (first exacerbation???) of MS. I know there are a lot of mimics out there, etc. But, what else could this possibly be if my blood work shows that I have no vitamin deficiencies?

However, she was also told that if she were to stop tysabri she was pretty much guaranteed to have an attack of the MS. She has an agressive form of MS and other medications don't seem to work. We haven't seen much improvement with tysabri, but at least she hasn't had anymore attacks while on it. Can anyone shed more light on this for me? I was hoping to gather more information on this if anyone has it. Please let me know! Thanks!

I'm not on Tysabri, but want to bump this up so that your message doesn't get lost. My sister is on Tysabri, which she's been on for two years now. Her MS is not behaving like someone that has RRMS, as her MS is more like a train that keeps barreling down the tracks and is unable to be stopped. She was on Rebif for a year and she experienced a sharp decline over the course of the year. She started Tysabri, and her disease has slowed, but it's by no means stable.

However, I will try to provide you with some information regarding rituximab in MS. I will say though that as you know, the goal of therapies for MS is to prevent relapses and accumulation of lesions in the brain and spine. While being off medications for a few weeks or even months is probably not detrimental, in the long term, it is optimal for patients who can tolerate the side effects of MS medications to be on them.

The research side of my MS Practice has identified a CSF biomarker for disease activity. The research is featured on the cover of this month's Multiple Sclerosis Journal. http://tischms.org/news/tisch-ms-breakthrough-biomarker-research-featured-cover-article-october-2013-issue-multiple I'm a beneficiary of this discovery. I had been on Tysabri for 20 months. At 18 Months I converted to JCV +, and we discussed switching from Tysabri to Tecfidera.

MS is different for each of us, but if you are familiar with the 5 stages of death, MS runs along the same parallel, but we can go in and out of them and not in any particular order. Denial is my favorite when I am feeling good and have been good for awhile. My latest neuro thinks I've had MS since 1981 (no MRI then) and I went thru 3-4 before finding this one, 3 states away, and won't give him up for anything.

I do not have typical ms, but a variant that is still clinically not diagnosed. I have a great neuro @ Stanford & he is recommending I start on Tysabri ASAP. I read up about the JC virus, and regardless plan to begin treatment next week. I don't know anyone with ms or ms variants so I want to know more about Tysabri from people who are on it or have used it. What is your experience? Pros/cons? I have read about side effects but I want to hear your thoughts & how it made you feel.

He reiterated that point yesterday. There are pluses and minuses to all MS meds. For me a big Tysabri plus is that I only have to deal with it once every 4 weeks. The thought of daily or weekly self injections was not all that appealing to me. Right before I saw my neuro yesterday I saw my naturopathic doc. Her office is two doors down from his, in the same MS practice. They work together and each is aware of what is being discussed with the other.

I hope you will take the time when you feel up to it and post some details about your MS and treatment with Tysabri. It could be helpful to others. Again, welcome!

ve been battling a major exacerbation. Had 3 days soluMedrol IV and while my legs could once again hold me, still alot of other stuff I'm dealing with such as increased pain, crushing fatigue, brain fogs. Saw neuro today and he is putting me on ritalin 5 mg twice a day for the fatigue. I'm a little nervous about that but I read the archives and sounds like it might help. I had been on copaxone for a year and a half and had to stop for huge welts.

Recently diagnosed with MS (November) and they are starting me with the drug Tysabri. Trying to find out what to expect and if it is helping others with their symptoms? All new to this, really have no idea what I need to know or ask? Just looking for someone with some insight on what I will experience.

Hi BL- Welcome to Our Merry Band :-) I was diagnosed 2 years ago, at age 51, with SPMS. My first, and up until a week ago my only, DMD was Tysabri. When I was diagnosed we were able to connect seemingly random events over the previous 20 years. What seemed completely unrelated was related. All were symptoms of MS. Because I'd had MS for so long my doc thought I was out of reach of the injectables. At the time the orals were just starting to come on the market.

Tysabri ms exacerbation

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