Tiotropium trial
Common Questions and Answers about Tiotropium trial
spiriva
I take Spiriva Respimat (tiotropium bromide) 2.5 mcg/actuation, and Wixela (fluticasone propionate salmeterol inhalation powder) for my COPD. Is there a sequence I should be taking these meds in? Is there a time frame I should use between the two meds?
Yes, there are. Spiriva® HandiHaler® (tiotropium bromide inhalation powder) is one and Serevent® Inhalation Aerosol (salmeterol xinafoate) another. Each is a bronchodilator and capable of giving good relief of shortness of breath.
If from the lungs, you could be experiencing Spiriva® HandiHaler® (tiotropium bromide inhalation powder) withdrawal symptoms, depending on what type of lung problem was being treated with the Spiriva® HandiHaler® (tiotropium bromide inhalation powder). These symptoms, along with your arms feeling weak and heavy, could all be due to anxiety, but could also be symptoms of more serious disease of the heart or lungs. For that reason, you do need to see your doctor to sort this out.
This would include a long-acting bronchodilator, such as Serevent® Inhalation Aerosol (salmeterol xinafoate), Foradil® Aerolizer™ (formoterol fumarate inhalation powder) or Spiriva® HandiHaler® (tiotropium bromide inhalation powder) along with an inhaled steroid. Another potentially helpful, oral medicine is called theophylline. Your doctor may also want to prescribe this.
You should have your blood oxygen level checked, in case it is low and you would need supplemental oxygen.
Spiriva® HandiHaler® (tiotropium bromide inhalation powder) has a maximum duration of action of about 36 hours. To be safe, you would want to be off the medicine for 48 to 72 hours before the spirometry. It would have been preferable, but not mandatory to do the pulmonary function tests (PFTs) at the time the diagnosis of chronic lung disease was made especially if the diagnosis was unequivocal. The other important question would be, “Why 3 CT scans, presumably of your lungs, in 16 months?
Cause of low DLCO and drop in it from test 1 to test 1? I am currently on tiotropium bromide and salmeterol/fluticasone propionate. My reason for posting this is one doc is pessimistic and the other highly optimistic.
Thank you.
Spiriva contains tiotropium bromide which is an anticholinergic bronchodilator. So, yes, both have action against acetylcholine recptors and both are efefctive bronchodilators. You can take any one of them.
Indacaterol is an ultra-long-acting beta-adrenoceptor agonist. So, it gives bronchodialation for a much longer time. It is a more recent drug so long term efficacy data are not available. However, available data does show a marked benefit in individuals with COPD.
Someone in my support group here is in a trial with Kaiser and taking SOC plus the Plough Shearing SI that has a number instead of a name. She's doing very well and will be done in 3 weeks.
boc trial is working good for me. I went in with a viral load of 13 million, in 2 weeks i had a viral load of 2 million. 1a . there are others here who have just about cleared. they will chime in.i will let you know next tuesday about results for 6 weeks. thats with n2 weeks of boc added.
Its been a couple years since I have been here. I did a trial in 2013 with someone that was dosing based on tsh and I eventually gave up. Now looking back I have discovered that I probably was not absorbing the medication. I also know that supplementing with iodine likely sabotaged any progress I was making since is causes tsh to rise in addition to tanking my iron. These are my observations based on the last two years of monthly labwork.
Most trial exclude post-transplant patients. The only trial that would be conducted would be through transplant centers
Have you spoken to your transplant center? They would know about any clinical trials that they will be conducting that you would qualify for.
You will need to be under the care of a transplant center if you should make any changes to the drugs you are taking.
You can get the trial number from the informed consent and maybe send out a message to see who is in the same trial. I was in a trial with IFN, RBV, GS9451 and GS5885. Had to drop after 12 weeks due to viral load going back up as a result of resistance. This was my second attempt at tx - was a non responder the first time. Good luck and hope that you get UND and SVR.
Hi, Yes that is the one!. They are taking four subjects from this office for the study. Yes, Giddyup is a 1a. Our only hesitation this time (he did the infergen trial for Intermune) is starting the whole combo therapy again , been there done that twice already, and he was exhausted just on mainentance for a year and a half... we have about a week to decide. but they drew bloods yesterday to be sure he qualifies, and the nurse said this moring that his platelets were good...
I have had an unprotected intercourse with someone who is a participant in an HIV vaccination trial at Walter Reed. What exactly is that study as I am having a hard time finding info on it. Do they use surface antigens? Am I at any risk? Any info will be appreciated.
Sincerely,
Ivan.
Also vertex said trials would start in April, how will any new sites that are added get set up and screen patients that fast to start the trial this month? Nothing moves fast with drug companies or the FDA. Thank the Lord that HCV is a slow moving disease for the most part.
I know there are around 1000 people in the phase III trial but was wondering how it is broken down to how many in each of the 3 arms. I specifically wanted to find out what % will be in the placebo arm and if I enter the study what chance i would have of getting Telaprevir. I seem to recall reading this breakdown or maybe it was on the last Vertex webcast? if someone could post a link that has the breakdown of arms it would be greatly appreciated.
Pending results from the Phase 1a trial, Vertex expects to initiate in mid-2008 a Phase 1b trial of VX-500 in HCV patients.
Nothing here that appears to have blockbuster potential as yet…with the potential exception of VX-500, which is their follow-on HCV protease inhibitor drug, currently in pre-human testing. Ideally this would be ready to take over from telaprevir—with better efficacy and milder AEs—around 2013 or so.
http://caps.fool.com/Ticker/VRTX.
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