We know the tumor is in a slightly different area than it was originally. He is in treatment (Temodar for the second time) for the third recurrence of his tumor. We have always been told it is in an area where surgery has not been an option. The oncologist does say he believes it is a higher grade. We think he believes it is glioblastoma but he won't say that definitely without doing another biopsy.
A month ago my husband (41) had a tumor resection of a GBM in the left temporal/frontal lobe. He is still recovering from surgery and has begun cancer treatment (temodar& radiation) a week ago. He has a previous accident injury where he has struggled with neck pain for ten years. He has been on suboxone for probably 7 years now. He is currently taking his suboxone but is not getting any relief for his head pain.
If a person is treating with the PI drugs and fails to get SVR.does it mean that you cant use the PI`s ever again.this is what im gathering from what ive been reading ...looks like its do or you know what....man...sometimes i wonder how i deal with all thie stuff.
Maybe one day they will use the PI as maintenance for the ones who dont respond to SOC and PI drugs.Ive heard of aids people liiving a lot longer now because of the PI`s too.Some are with aids for 25 years and still doing ok.
"An apple a day keeps the doctor away, But if the doctor is cute forget the fruit.
Schering-Plough CEO Fred Hassan said in an interview that those drugs include Nasonex, Pegintron for hepatitis, cancer drug Temodar, the Nuvaring contraceptive and the two cholesterol drugs, all of which have patent protection until 2014 or later.
Doesn't appear Pegintron will be any cheaper for a long time.
Patient made decision to treat his anaplastic astrocytoma with surgery and Temodar only. No radiation! What is the prognosis for this 33 yr.old male.
Since the diagnosis of Glioblastoma grade 4 in August, my husband has had the tumor removed and completed the round of radiation and chemotherapy - temodar. Recently I have noticed him being very short fused and argumentative. The slightest thing sets him off as if he had been personally attack. I have also noticed depression setting in. I'm assuming this is all part of the treatment and diagnosis.
If your talking about the third drug being the PI as info they have not been approved for genotype 2, 3 and 4. If you are genotype 1 some insurance companies will initially deny the PI because it is so costly. Your doctor will have to start an appeal process with the insurance company which may take a little time but usually in the end the PI is approved.
I vote for boceprevir since it has a 4 week lead-in before starting the PI. If you clear in the first 4 weeks of TX, you are responsive to interferon and do not need to add a PI with all its extra side effects and risks.
Well, to state the obvious, you'd have to have a date for the PI availability in order to time it right. But I wouldn't like to have a tx plan with a date in it that I couldn't trust.
However, in general I've wondered too how it would work out to do the PI in the last 4 weeks of tx when the virus is either already dead or on it's last legs, just to make sure and finish it off. That might work well for some potential relapsers.
Vertex knows this and is working on the second generation of PI. I love this link about all the meds in the pipeline and their status.
http://www.hcvdrugs.
The Abbvie regimen contains Paritaprevir, which is a PI, so those who have failed in the past with a PI (Telaprevir, Boceprevir, Olysio) should not treat with the Abbvie drugs.
Treating with Harvoni is the AASLD recommended way to go.
The AASLD guidelines for those who failed with a PI are copied and pasted below. Go towards the bottom and you will see that the AASLD does NOT recommend the Abbvie drug regimen for those who failed with another PI.
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