ve resigned myself to using tobradex w/my opth monitoring IOP levels, and I also use the other treatments. My opth seems okay with tobradex long term, but I wish had the peace of mind of knowing that I had a permanent treatment.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
Prograf is a medicine that slows down the bodys immune system. For this reason, it works as an anti-rejection medicine. Prograf helps patients who have had a liver/kidney transplant protect their new organ and prevent it from being rejected by the body. This medicine can cause the amount of potassium in your blood-stream to increase.
i wouldnt lower the tacrolimus dose further
Blood tests show that the BUN and creatinine levels are slightly elevated. If prograf does effect the kidneys, what measures can be taken to help minimize damage to the kidneys and help protect the kidneys???
Thank you in advance.
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
and the Creatinine level at that was 1.5 - 1.6. The doctor reduced the tacrolimus dose to .5 mg morning and evening and since then the Creatinine level is slowly increasing. It is now between varying between 2.1 and 2.4. The TAC level is also low and reduced from 4.5 to 3.4 to 2.4 when last checked 2 months ago. Had a biopsy 2 months back and the report was OK.
Pl suggest.
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
Although steroids, are commonly used for the treatment of atopic dermatitis, there are certain other agents also which are used like immune modulator drugs e.g. tacrolimus. These are available in the form of ointments and tend to prevent the recurrence. You can discuss with your dermatologist regarding the right use.
There are certain other non-pharmacological measures which are equally important in treating atopic dermatitis.
Although steroids, are commonly used for the treatment of atopic dermatitis, there are certain other agents also which are used like immune modulator drugs e.g. tacrolimus. These are available in the form of ointments and tend to prevent the recurrence. You can discuss with your dermatologist regarding the right use.
There are certain other non-pharmacological measures which are equally important in treating atopic dermatitis.
Although steroids, are commonly used for the treatment of atopic dermatitis, there are certain other agents also which are used like immune modulator drugs e.g. tacrolimus. These are available in the form of ointments and tend to prevent the recurrence. You can discuss with your dermatologist regarding the right use.
There are certain other non-pharmacological measures which are equally important in treating atopic dermatitis.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
Although steroids, are commonly used for the treatment of atopic dermatitis, there are certain other agents also which are used like immune modulator drugs e.g. tacrolimus. These are available in the form of ointments and tend to prevent the recurrence. You can discuss with your dermatologist regarding the right use.
There are certain other non-pharmacological measures which are equally important in treating atopic dermatitis.
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
I sincerely hope that helps. Take care and regards.
Blood levels of tacrolimus (Prograf) can also be equally affected for the same reason as with cyclosporine. [both drugs are calcineurin inhibitors]
* omeprazole (Losec, Prilosec)
* oxycodone (Oxycodone is metabolized by the cytochrome P450 system, specifically CYP3A4, of which the bergamottin flavonoid is a strong inhibitor)
* hydrocodone (The hepatic cytochrome P450 enzyme CYP2D6 converts it into hydromorphone, a more potent opioid.
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
If still the symptoms do not improve then please get a clinical examination done by a dermatologist.
I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
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