tacrolimus level patients

Hi Doctor, what is your opinion of when Incivek will be approved for transplant patients? Are they running or planning trials for post transplant patients or how does it normally work to get the process approved in this case?

Since I was on tacrolimus only(as Mycophenolate causes TLC to go down in two occasion), sirolimus 1mg is started along with reduced tacrolimus(2mg BD, Tac level ~4.5). But the creatinine is still high(1.8). It seems some side effect of Sirolimus is also coming as the TLC is 3400 and platelet is 80,000. What do you suggest to bring creatinine under control? What is the way to determine the exact required dose of tacrolimus?

The CIs - cyclosporine and tacrolimus levels are increased significantly by the PIs - as much as 70% increased levels - I believe. I do not know of any transplant centers who have begun treatment with Invcivek or Victrelis in their liver transplant population. It appears as though we're going to have to wait until they've figured out the dosages.

THere is no Zylet ointment that I know of. Even Zylet or Lotemax can affect the IOP significantly in some patients. Tobradex ointment will have basically the same effect on IOP as Tobradex drop. I might have other suggestions if I had more info about your case.

My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?

OLT recipients with HCV were randomized to receive tacrolimus+daclizumab (steroid-free) vs. tacrolimus+corticosteroids during 1999-2001 and then tacrolimus+mycophenolate mofetil (MMF)+daclizumab (steroid-free) vs. tacrolimus+MMF+corticosteroids during 2002-2005. Patients in the steroid-free arm of both periods received no steroids except for treating biopsy-proven rejection.

5 mg morning and evening and since then the Creatinine level is slowly increasing. It is now between varying between 2.1 and 2.4. The TAC level is also low and reduced from 4.5 to 3.4 to 2.4 when last checked 2 months ago. Had a biopsy 2 months back and the report was OK. Pl suggest.

The protocol at my institution is to stop tacrolimus on Day 1 of protease inhibitor therapy and measure tacrolimus levels 3 and 7 days later, and then adjust the dose of tacrolimus according to the level. At least in the small number of patients we have seen, a tacrolimus dose of 0.5 mg once per week is sufficient to maintain a drug level of 3–5 ng/mL.

Steroid induced rosacea or dermatitis is an adverse effect of using steroids. Some patients develop steroid-induced rosacea within weeks of applying a topical steroid; others may not experience it for years. Avoiding rosacea triggers, such as caffeine, spicy foods, and alcohol, also may help clear the skin. Also use of antibiotic creams, antihistaminics, sun screens and tacrolimus(available by prescription) helps but consultation of a dermatologist is required first.

Your hepatologist should have the last say - irregardless of what the other doctors think. Yes, Viagra is a problem for patients dealing with liver and kidney disease. Unless my liver team tells me it's ok, I don't do it. Just be careful.

He was tested positive for ebv but afetr reduced tacrolimus dose by1 mg per day his ebv is negative. Also his biopsy reports does not indicated auto Immune hepatitis.Please let me know what is the right mathod or treatment to get his IgG and protien level normal. Thank you for your previous respose.

The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.

What/how much are you taking Immunosuppressants and tacrolimus level ? Might be a slight rejection ? I recommand to talking to the transplant team.

I am taking Tacrolimus 3mg and Myfortic 360mg twice a day, FK level is around 5. Am I going to take these two immunosuppressants (probably same dosages) for life or might be reducing the dosage ?

His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys? Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe? Sir ,will wait for your kind reply. Thanks.

Transplantation was done in Egypt 25-5-2008, I did very well for 2 months and then ler enzyme start to rise , liver biobsy revealed mild rejection, adjustment of tacrolimus was done.but liver enzymes cntinue to rise.MRCP was done and reveaed mid dilatation of hepatic ductes and ERCP and stenting was done 1.5 month ago. Although bilirubin both direct and total, albumin, prothrombin, C.B.

Steroid induced rosacea or dermatitis is an adverse effect of using steroids. Some patients develop steroid-induced rosacea within weeks of applying a topical steroid; others may not experience it for years. Using tacrolimus often resolves the itch, redness, and tenderness of steroid-induced rosacea but it should be taken after a dermatologist’s guidance. Avoiding rosacea triggers, such as caffeine, spicy foods, and alcohol, also may help clear the skin.

The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions. I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.

im terribly worried right now. im currently taking tacrolimus medication aswell. should i be worried? i feel perfectly fine though. i dont have any symptoms. if i was to take a blood test in 4 days, will my sgpt and sgot level go high? please help. thank you.

I was OK with my test results until I read that Elidel was chemically similiar to tacrolimus a calcineurin inhibitor that is used in transplant patients. I test orally via the OraQuick test 3,4,5, and 8 months out. All negative. I also had a 6 month blood EIA test done through Quest labs with a non-reactive result. My questions are as follows: 1. Given the length of time I have been using Elidel do you think it could have prevented my body from developing antibodies to HIV.

I was initially taking Tacrolimus and then I was switched to Sirolimus. I cannot remember why my immunosuppressive was changed but Sirolimus was pretty new then and maybe my surgeon wanted to try it and see how I did. I wasn't very fond of it as I recall. It came in small packets and was an oily solution. It's been a while but I do remember that. I probably mentioned this to my surgeon and that could be the reason that he switched me back.

there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.

im terribly worried right now. im currently taking tacrolimus medication aswell. should i be worried? i feel perfectly fine though. i dont have any symptoms.

Tacrolimus level patients

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