tacrolimus level

Since I was on tacrolimus only(as Mycophenolate causes TLC to go down in two occasion), sirolimus 1mg is started along with reduced tacrolimus(2mg BD, Tac level ~4.5). But the creatinine is still high(1.8). It seems some side effect of Sirolimus is also coming as the TLC is 3400 and platelet is 80,000. What do you suggest to bring creatinine under control? What is the way to determine the exact required dose of tacrolimus?

My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?

5 mg morning and evening and since then the Creatinine level is slowly increasing. It is now between varying between 2.1 and 2.4. The TAC level is also low and reduced from 4.5 to 3.4 to 2.4 when last checked 2 months ago. Had a biopsy 2 months back and the report was OK. Pl suggest.

He was tested positive for ebv but afetr reduced tacrolimus dose by1 mg per day his ebv is negative. Also his biopsy reports does not indicated auto Immune hepatitis.Please let me know what is the right mathod or treatment to get his IgG and protien level normal. Thank you for your previous respose.

The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.

What/how much are you taking Immunosuppressants and tacrolimus level ? Might be a slight rejection ? I recommand to talking to the transplant team.

I am taking Tacrolimus 3mg and Myfortic 360mg twice a day, FK level is around 5. Am I going to take these two immunosuppressants (probably same dosages) for life or might be reducing the dosage ?

His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys? Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe? Sir ,will wait for your kind reply. Thanks.

Transplantation was done in Egypt 25-5-2008, I did very well for 2 months and then ler enzyme start to rise , liver biobsy revealed mild rejection, adjustment of tacrolimus was done.but liver enzymes cntinue to rise.MRCP was done and reveaed mid dilatation of hepatic ductes and ERCP and stenting was done 1.5 month ago. Although bilirubin both direct and total, albumin, prothrombin, C.B.

s hard to perform my job or other daily tasks when my eyelids are so inflamed. I guess steroids are the only option until they develop something better. Is Tacrolimus a promising nonsteroidal option?

The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions. I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.

im terribly worried right now. im currently taking tacrolimus medication aswell. should i be worried? i feel perfectly fine though. i dont have any symptoms. if i was to take a blood test in 4 days, will my sgpt and sgot level go high? please help. thank you.

there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.

im terribly worried right now. im currently taking tacrolimus medication aswell. should i be worried? i feel perfectly fine though. i dont have any symptoms.

The CIs - cyclosporine and tacrolimus levels are increased significantly by the PIs - as much as 70% increased levels - I believe. I do not know of any transplant centers who have begun treatment with Invcivek or Victrelis in their liver transplant population. It appears as though we're going to have to wait until they've figured out the dosages.

AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.

i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.

Oral antifungal drugs and immunomodulators such as tacrolimus and pimecrolimus are used in very severe cases. Best would be to consult a dermatologist and get biopsy skin done to confirm the diagnosis. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor. I sincerely hope that helps.

Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful. If still the symptoms do not improve then please get a clinical examination done by a dermatologist. I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.

My question regards Zortress (everolimus) which I have just started taking (3mg daily) along with my other post transplant meds. I have been told that once the Zortress blood level becomes stable I will be stopping my 720mg of Myfortic and remain on 4mg of Tacrolimus and 5mg of Prednisone. I was told that I am taking Zortress because of its anti-cancer properties since I have a very high risk of HCC recurrence due to my pre-transplant AFP numbers.

OLT recipients with HCV were randomized to receive tacrolimus+daclizumab (steroid-free) vs. tacrolimus+corticosteroids during 1999-2001 and then tacrolimus+mycophenolate mofetil (MMF)+daclizumab (steroid-free) vs. tacrolimus+MMF+corticosteroids during 2002-2005. Patients in the steroid-free arm of both periods received no steroids except for treating biopsy-proven rejection.

Not the right place for this question. Sorry.

Tacrolimus level

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