t be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet. Also, it's $95! Anyone have any experience with this? Anyone whose pup responded to cyclosporine after not responding to tacro?
I was initially taking Tacrolimus and then I was switched to Sirolimus. I cannot remember why my immunosuppressive was changed but Sirolimus was pretty new then and maybe my surgeon wanted to try it and see how I did. I wasn't very fond of it as I recall. It came in small packets and was an oily solution. It's been a while but I do remember that. I probably mentioned this to my surgeon and that could be the reason that he switched me back.
My opth has diagnosed me with blepharitis, I use sterilid w/ compresses and take flaxseed oil, and I also use preservative free eyedrops for moisture. However nothing has worked to my satisfaction besides tobradex which I've used for about a year and half- my eyelid inflammation is pretty severe even with the other treatments, however w/ tobradex my symptoms are almost nonexistent.
The treatments of this condition are application of topical corticosteroids (betamethasone, clobatesol, flucinolone) which will reduce the inflammatory process. Topical immunomodulators like pimecrolimus and tacrolimus can be used in severe conditions.
I hope it helps. It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor.
I lost my insurance after 13 years post-transplant.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
Antihistaminics, topical steroids, PUVA therapy, retinoic acid and tacrolimus are the available treatment options for lichen planus.It is best to clarify your doubts by your dermatologist. I hope it helps.
Take care and regards!
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
I am taking Tacrolimus 3mg and Myfortic 360mg twice a day, FK level is around 5. Am I going to take these two immunosuppressants (probably same dosages) for life or might be reducing the dosage ?
Can tacrolimus eye drops and Cyclosporine ointment cause cancer in dogs? My precious dog, baby and best friend was diagnosed just last week with Transitional Cell Carcinoma in his bladder. It is a rapid growing cancer. I am completely heartbroken and am wondering if there was something I could've done to prevent this. He has been on these two eye medications for about a year. His name is Duke and he is a beautiful tri-colored collie and is a little over 10 years old.
The protocol at my institution is to stop tacrolimus on Day 1 of protease inhibitor therapy and measure tacrolimus levels 3 and 7 days later, and then adjust the dose of tacrolimus according to the level. At least in the small number of patients we have seen, a tacrolimus dose of 0.5 mg once per week is sufficient to maintain a drug level of 3–5 ng/mL.
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