Not so sure about tacrolimus. Look at the law offices looking for people treated with tacrolimus creams. Still some concern out there about serious side effects. Don't forsee approval anytime soon in U.S.
As a side note, have your doctor look for demodex follicularis. Some research indicates that they can worsen lid margin disease.
i wouldnt lower the tacrolimus dose further
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
The standard therapy options include intravenous immunoglobulin and plasmapharesis, corticosteroids, azathioprine, cyclophosphamide, etanercept, mycophenolate mofetil, interferon alpha 2a and tacrolimus. Current ones are interferon beta 1a, rituximab, and high dose cyclophosphamide. Your neurologist needs to apprise you of the long-term side effects since prolonged therapy are required. Botox shots are not known to be used in therapy.
I didn’t bother reporting the adverse reaction since the cream’s listed side effects include permanent discoloration and skin burns/bubbling/lesions/etc.....sounds like the manufacturer is well aware of these problems....I just wish the Dr would have warmed me. Looks like I better get used to living with the damage since I’ve already been tested for fungal infections.
I am 6 years post liver transplant from genotype 3 Hep C. My doctors want to start treatment to clear the virus. I take Prograf for the liver transplant and I know Naragenin affects the Prograf levels. My question is if during treatment I also took Naragenin and my prograf levels were closely watched and adjusted for the Naragenin effects, wouldn't I have a better chance of clearing the virus.
Topical antifungals and mild steroids are the usual treatment and combination of the two can be used to treat stubborn patches. Oral antifungal drugs and immunomodulators such as tacrolimus and pimecrolimus are used in very severe cases.
I hope it helps. Take care and regards.
I don't see any reason you can't tell me how much you take/have taken. That's not medical advice.
(interestingly though, a few days before at the vet, the schirmer test was 12 in both eyes). Now 6 weeks later, the right eye has a 6 and the left eye still has 0. The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus.
The peeling that you are having is due to side effects of steroids. My sincere advice would be to consult an allergist and get allergy testing done. In this a small amount of allergen is introduced into the skin of the forearm and the reaction of the skin is noted. If there is any redness then that person is allergic to the allergen introduced. You can also get blood tests like RAST done.
You can take OTC antihistaminics like Benadryl or Claritin.
Oral antifungals are not without side effects and should be used with caution after consulting a dermatologist.
It is very difficult to precisely confirm a diagnosis without examination and investigations and the answer is based on the medical information provided. For exact diagnosis, you are requested to consult your doctor. I sincerely hope that helps. Take care and please do keep me posted on how you are doing.
Lichen sclerosus is a chronic disease which effects usually the genital areas. The exact cause is not known and can be too active immune system and hormone problems. Some people have also proposed a genetic and hereditary basis of disease.
Treatment consists of strong cortisone cream or ointment on the skin. Other treatment options include Retinoids, vitamin A-like drugs, Tacrolimus ointment and Ultraviolet light treatment.
I am 55 yrs old female and went for a physical and was told i had high blood presure, that day it was 144/92. I had a blood test and it showed high cholesteral 257. Doctor put me on 10 MG Lisinopril. I took the tab for 5 days on the fifth day my heart was pounding so hard in my chest and i felt like someone was sitting on my chest. This happened a few more time over the next week and it would go away after a few min.
22 days on sovaldi-olysio-no side effects,not even a headache.And to this life long non responder who has done and failed with everything that has been on the market,this combo is working.Cant believe I am getting better and not suffering like I did with all the previous poison.Its like Dr. Bones McCoy from Star Trek brought this stuff back from the future.
I woke this morning with aches and pains and have been experiencing a headache on and off all day that is when I am not SLEEPING. Honestly I am not complaining especially since I had expected much worse. My question is do the symptoms change or/and get worse as treatment continues. I would assume they do get worse since the meds build up in your body. I have 3 kids ages 16,11,and 7.
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