Hi Ann
I was on Methotrexate for quite some time, and, honestly, I did not experience any effects therefrom. But in terms of the ability to procreate, I do believe there are effects, and they may affect this, so care should be used.
I do know, however, that this is a powerful Chemo drug, and I was on it for several months, but I also have Crohn's Disease, and I believe for ME, it was an attempt to manage both diseases at the same time, as they were both being problematic at the same time.