The vitamins do make a huge difference...we are on day#3 of methadone wd and we pushed heavy vitamins, including B12 injections, we drink calmag about 5 or 6x daily, aminos, check out our journal if you would like to see exactly what we take. It helps a lot overall but RLS is a big issue for my fiance (I think he may even have a touch of RLS aside from this). He has been wrapping his legs in ace bandages...a little pressure helps a lot. Also, if you can, add epsom salt to your bath water.