congestive heart failure , cholestasis (congestion of the bile ducts) , cirrhosis, hepatitis , liver ischemia (blood flow deficiency),
liver necrosis,
liver tumor, high alcohol intake, use of hepatotoxic drugs (drugs toxic to
liver). Most liver diseases are characterized by greater ALT elevations than AST elevations except cirrohsis and alcohol abuse. ALT also rises in bile duct obstruction due to stone.