I've had severe depression all my life. I had a schizoid episode when I was a teenager. Mental illness runs in my family. I take pristiq, lamactil, adderall, and clonazepam for panic attacks. I'm usually pretty stable on my meds. But I still don't understand why the hours of 1-5 p.m. are the worst for me I'm great in the morning and evening and night, but mid afternoon I go down hill and very depressed or sad. Also the weekend is very hard for me.