My current dose is Prograf 3 mg AM/ Prograf 3 mg PM and Rapamune 4 mg AM. The intent is to convert me to 100% Rapamune because of the nephro-toxicity of the Prograf and my young age and because of the anti-cancer properties of Rapamune. Data, while horribly limited, has shown Rapamune's anti-cancer properties have had success against vascular tumors such as mine so EHE, in this case chronic, is part of the cancers Rapamune affects (some cancers it has no effect).
If i lower my prograf lower than 6.5 through rate i start getting discomfort right side .i am having cognitive issues on prograf that are getting very hard to live with, seems like it got alot worse after my last of three mri with contrast in two years. was hospitalized two days after last contrast exsposure white blood count went to1000, headach, fever urine got exstremly foamy, severe itching ,tighting and rashd eveloped on lower legs two weeks after.
Many doctors will tell you that you will take immune suppression medication for life. However, research has shown some people can get off of them. In fact one researcher claims 20% of all liver transplants recipients don't need the meds at all. Studies are currently underway.
My hepatologist told me, that some people can stop taking them after about 5 years. The theory is that your stem cells replace the ones in the donor liver actually making it your own.
I believe that diarrhea can cause an elevation in Prograf level. Taking Prograf with food can decrease absorption and result in a lower Prograf level. This is even more pronounced if you take it with fatty food. If Prograf doesn't upset your stomach it is best taken about 1 hour before eating - on an empty stomach.
The range on my labs sheet is 4 - 16 so you are well within range.
Pentamidine (aerosol) 1x monthly, Prograf 2mg 2x daily, metroprolol tartarate 12.5mg 2x daily, magnesium oxide 400mg 2x daily, oscal, multi vitamin, vitamin d3 1000iu 1x daily. Thanks.
I went into rejection twice in the hospital and because of this my transplant team saw it best to put me on 5mg of prograf twice a day as well as 4 mg of rapimune, which by the way was off label and i had to sign a release form for. Just within the past 2 months they lowerd my dosage of rapimune to 2mg but kept the prograf the same. My question to you is exactly how suppressed is my immune system?
hi mike! thanks for always being there anytime i needed an answer and help for our situation. So far so good, transplant was really a blessings we dont expect, my hubby now were very healthy, strong and active. we're enjoying a quality life than ever before thanks God of coarse for the chance given to us. His last laboratory result and ultrasound was all fine, that was maybe the reason why his dr. didnt prescribe yet treatment like riba or interferon.
some patients metabolize the prograf much more than others, especially after a partial liver transplant. It is still early after the transplant. as long as the liver tests are OK, he shouldn't worry. They should slowly push the dose of the prograf up, while he is taking the cellcept.
I am 6 years post liver transplant from genotype 3 Hep C. My doctors want to start treatment to clear the virus. I take Prograf for the liver transplant and I know Naragenin affects the Prograf levels. My question is if during treatment I also took Naragenin and my prograf levels were closely watched and adjusted for the Naragenin effects, wouldn't I have a better chance of clearing the virus.
My history: liver transplant 1 year ago, had 2 moderate rejections and 1 mild since transplant. At present time having moderate rejection, recently had one portal stent and 8 Bilary ERCP's to remove stones and sludge and had stenting done, and at the present time there are no blockages. Was on Rapamune (5mg a day) prior to hernia surgery and then week before hernia surgery was put on Prograf (4mg a day) and taken off the Rapamune. I have been on Progaf since hernia surgery (8 weeks ago).
If suppressants are at the correct trouph levels, say, Prograf and Rapamycin, what are the next steps - switch suppressants, treat?
t understand the relationship between treatment and Prograf dose. It sounds logical to think that the higher the Prograf dose the less likely TX will be successful and, at the extreme, I think that's probably true. But, whether 3 mg per day or 6 mg Prograf per day makes any difference is a question I cannot answer.
When I treated there was a reluctance to dose the way a non-transplant patient would have been dosed and that can be and, in my case, was problematic.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
Prograf is a medicine that slows down the bodys immune system. For this reason, it works as an anti-rejection medicine. Prograf helps patients who have had a liver/kidney transplant protect their new organ and prevent it from being rejected by the body. This medicine can cause the amount of potassium in your blood-stream to increase.
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