When Norephinepherine depletion in the brain is a key contributor to your severe depression, Effexor and
Pristiq can work wonders to getting you productive and back
in remission.
There is a reason Effexor XR makes 3.5 Billion a year in sales per year.... Because it flat out WORKS many times for people that fail on SSRI's.
Sorry, but I must defend Effexor XR. Yes it can be a heavy hitter, but when the depression gets real bad it can often be just the ticket to remission.