I have fibromyalgia, degenerative arthritis and yes, clinical depression. When I take Savella and Pristiq together, it works wonders. When both my pain dr and my psychiatrist got together and said I couldn't take them together, I became very depressed after getting off of Savella. I didn't want to kill myself, but I sure didn't want to live. Lyrica put me to sleep in horrible ways, Cymbalta doesn't work for me and anything like Prozac or Lexapro or Zoloft is candy to me.