I was on Effexor at 300Mgs a day at one time.
For a good many years it worked wonders
for me. Many years later and many drugs later I tried
Pristiq, but it didn't work so well for me even at a 100Mg dosage. Maybe it was just too much like Effexor and since that pooped out on me the Pristiq wouldn't work for me.
One thing is for sure, Effexor was a rough swith to a different med, but Pristiq OMG! The withdrawl from 100Mg of Pristiq was murder.