2% to 3%
Leads to advanced fibrosis in 5% to 15% of patients
Few therapies exist
Pioglitazone
A thiazolidinedione
Active in diabetic patients with NASH
Antiinflammatory, antifibrotic, insulin sensitizing
Current study sought to evaluate safety and efficacy of pioglitazone in nondiabetic patients with NASH
Schematic of Study Design
Eligibility
Main inclusion criteria
Biopsy-confirmed NASH
Fat in liver > 5% plus liver injury and liver inflammation with or withou
Meanwhile, he and his colleagues are investigating the biological mechanisms by which vitamin E or pioglitazone might reverse fatty liver disease. Cusi’s research group is testing pioglitazone against fatty liver in Hispanics, who seem prone to the disease, and in people with diabetes."
http://tinyurl.
Bitter gourd and spent turmeric at 10% level were tested for their efficacy on glycosaminoglycan metabolism in various tissues viz., liver, spleen, lungs, heart and testis in control, diabetic and treated rats. The glycosaminoglycans (GAGs) were isolated from defatted and dried tissues. The contents of sulfated GAGs decreased in all the tissues and the decrease was more prominent in heart and testis.
For women who are unresponsive to clomiphene,the oral hypoglycemic agents like metformin could be of little help, or pioglitazone, may bring resumption of regular cycles and ovulation. These agents reduce the hyperinsulinemia and hyperandrogenemia in PCOS.
These are actually medically prescribed medicines for PCOS.As this syndrome is very common in women the case is often individualised and treatment option will be processed and prescribed.Fell free to talk to your Doc.
Is the pitting edema progressive? Are you on pioglitazone? or rosiglitazone? Answers to these questions would further help.
I am obese (300lbs), diabetic (type 2) and require medication to control hypetension. I take the following medications – Metformin, Pioglitazone, Victoza (liraglutide), Amlodipine, Ramipril, Bendroflumethiazide, Asprin and Statin.
I have a strange and embareasin problem. I hope someone out there may be able to offer some insight. I have always had sensitive nipples but in the last few days sensitivity in my left nipple has gone crazy.
HI,
It sounds like your wife will definitely need an additional medication--if not restarting the Pioglitazone, then an alternative. There are lots of different diabetes medications available that will help. Those glucose levels are indeed too high and should be addressed soon. Please ask your wife to contact her doctor as soon as possible(I suggest within the next 2 days a most) and discuss being started on another medication to bring her levels down.
Evangelin posted about this youtube video. "Sugar , the bitter truth"
It is a long video , but what I did not know before watching it is that
High Fructose Corn Syrup metabolically is as bad as alcohol for the liver.
The majority of processed foods we find in the supermarket have High Fructose
Corn Syrup which can majorly effect obesity and fatty liver.
Other newer insulin-sensitising medicines include pioglitazone. This is not currently recommended for PCOS. For certain people with PCOS, a specialist may advise that metformin be taken. However, further research is needed to confirm the role of these medicines in the treatment of PCOS.
Good article on magnesium but not clear about efficacy of magnesium oil. The seller really hypes it's effectiveness, but I'd like an unbiased opinion.
Hi,
Docetaxel (Taxotere) and carboplatin is an approved and effective treatment for ovarian cancer. Docetaxel and paclitaxel have nearly similar efficacy in this setting.
Docetaxel is known to cause less neuropathy than paclitaxel.
All the best, and God Bless!
It was recently documented that the NAP REP 2139 was capable of reducing serum HBsAg levels during chronic HBV infection, improving the efficacy of immunotherapy and facilitating establishment of functional control off treatment.
s benefits are less clear, according to the latest findings from the Pioglitazone vs Vitamin E vs Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis (PIVENS) trial, reported online April 28 in the New England Journal of Medicine......."
See: http://www.medscape.com/viewarticle/721221?sssdmh=dm1.615392&src=nldne&uac=39980BG
I hope this helps.
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