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In people who have LQTS, problems with the ion channels in the heart cells may disrupt the timing of the electrical activity in the ventricles. The ion channels may not work properly, or there may be too few of them. In this situation, the heart may suddenly develop a fast and abnormal heart rhythm that can be life threatening.
Many cases of LQTS are inherited, which means you are born with the condition and have it your whole life. There are seven known types of inherited LQTS.
Your question involves electrophysiological/chemical (electrolytes) phenomonon that polarizes (charging...chamber filling), and repolarization (discharging...contractility of chamber) heart cells. In arterial smooth muscle cells, intracellular calcium paradoxically controls both contraction and relaxation.... The mechanisms by which calcium can differentially regulate diverse physiological responses within a single cell remain unresolved....
Hello itdood,
In googling past thread on this site, you made reference to magnesium helping your PVCs, then them getting much worse. Well, this morning (even prior to reading such a thing) I had a feeling that was happening to me.
A couple months ago taking two 200 mg Magnesium Citrate tabs a day was like magic; it just calmed my heart (and calmed me in general) so much. Now it's gone, but I'm afraid to stop the magnesium.
Medications like fluconazole block potassium channels. In susceptible people, this can prolong the QT interval on the EKG and lead to ventricular tachycardia called torsade de points. There is a whole list of medications that can have similar effects:
http://long-qt-syndrome.com/lqts_drugs.html
http://www.americanheart.org/presenter.jhtml?identifier=993
This is a relatively rare condition. Defibrillator discharges usually have nothing to due with QT intervals or medications.
Arteries have muscles, smooth muscle, and use calcium to create energy. Calcium is taken from the blood through tiny channels in the artery lining. Calcium channel blockers do what they say, they stop the channels being able to absorb so much calcium, inhibiting their energy level, stopping the ability to spasm.
PVCs and PACs occur when heart cells other than the typical pacemaker cells generate an electrical impulse and then a muscle contraction and heart beat. These may occur rarely or in some cases very frequently. Similarly, some people aren't aware of these while other people feel very symptomatic with them.
Once an electrical cell generates an electrical impulse, this electrical impulse causes the ions to cross the cell membrane and causes the action potential, also called depolarization and it is the movement of ions across the cell membrane through sodium, potassium and calcium channels, is the drive that causes contraction of the cardiac cells/muscle. Then there is a relaxation pahase.
Electrical charge measured in microvolts would vary as shown on an EKG.
hypokinesis can also be the result of stunned cells. Stunned heart cells affected by a heart attack can be revitalized if blood/oxygen is quickly provided within a few hours to the area affected by an acute heart attack.
Akinesis is different from hypokinesis in that the heart cells affected are necrotic (dead). Stem cell therapy may be helpful for that condition.
Five years ago I had hypokinesis of the left ventricle wall and a low EF.
In either case, the doctor will generally start with rate control -- with either a beta blocker or calcium channel blocker. I personally take cardizem (a calcium channel blocker), which brings my persistent afib into a heart rate range of 60-90. Verapimil sounds like a good choice for your wife. Cardizem works well for me and I hardly notice any symptoms (and so don't need to consider a pacemaker). There are those where this doesn't quite work like in your wife's case.
You have suffered a great injustice, and I'm sorry for your experience. I do not know what the black substance was, or what the results of exposure may be. However, the skipped beats may be caused simply by confusion in the heart muscle itself.
Your heart cells are all capable of contracting and causing the heart to beat. Usually, this job is segregated to specific cells that most people refer to as the "natrual pacemaker.
Hi, am doing some research. please can you explain why an 89yr old with pacemaker kept her 70bpm pulse with a fever of 40 deg.C. Also what were the metabolic implications for her? Many thanks.
Nerves work when sodium (Na+) and potassium (K+) ions move in and out of the individual cells via special gated channels in each cell’s membrane (outer wall). The balance inside determines the action potential - how ready it is to transmit a signal or ‘fire’. (A similar process occurs in other types of cells where there needs to be a trigger for some other process to start.)
There are several types of potassium ion transport channels.
I suffer from permanent AFib, but I have no experience with a pacemaker. That said, I don't think there is anything a pacemaker can do about AFib. If you palpitations are irregular heart beats, and a heart rate that is higher than you would like, say over 100 bpm, it could be due some of to the AFib signals getting through. I take both a beta blocker and calcium channel blocker to reduce the number of extra heart beats I get from the AFib.
Potassium is a chemical element and it is part of the electrolyte that should be in balance with other lytes to adequately conduct an electrical impulse that originates with the sinus node in the right atrium. The mechanism of action is not completely understood, but what is when a voltage (unit of potential for conduction) and electrolyte there will conduction and passage of electrical impluses.
The spread of electricity throughout the heart muscle is possible because all heart muscle cells, not just pacemaker cells, are excitable. Usually, the heart muscle cells keep time more slowly than normal pacemaker cells. This allows the pacemaker cells within the SA node to be in control of generating and pacing the heartbeat.
t help everyone and the second line of defence is usually Calcium channel blockers. Tiny tubes (channels) in artery linings allow calcium to be absorbed into the artery muscle which is used in a chemical reaction to create energy, allowing the muscle to tighen the artery, making the area for blood flow less. However, calcium channel blockers prevent the absorption of calcium from the blood. The more the dosage the higher the restriction.
My husband , 61 years old, has a pacemaker and he suffers from severe leg cramps almost on a nightly basis. Is the pacemaker and leg cramps connected or could there be something else causng his leg cramps?
The spread of electricity throughout the heart muscle is possible because all heart muscle cells, not just pacemaker cells, are excitable. Usually, the heart muscle cells keep time more slowly than normal pacemaker cells. This allows the pacemaker cells within the SA node to be in control of generating and pacing the heartbeat.
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