niacin and insulin resistance

Insulin resistance is the major feature of the metabolic syndrome and depends on insulin secretion and insulin sensitivity. In chronic hepatitis C, insulin resistance and type 2 diabetes mellitus are more often seen than in healthy controls or chronic hepatitis B patients. Hepatitis C virus (HCV) infection promotes insulin resistance, mainly by increased TNF production together with enhancement of suppressor of cytokine (SOC-3); both events block PI3K and Akt phosphorylation.

Many who suffer from hypoglycemia have polycystic disease of the ovary associated with insulin resistance. Increased insulin levels can cause hypoglycemia. Excessive alcohol intake, hepatitis, kidney disease, certain medications, disorders of adrenal gland etc can all cause hypoglycemia. It can also be caused by poor eating patterns. Rarely is it caused by insulin secreting tumors called insulinomas.

The most common cause of AN is insulin resistance. Conditions associated with AN include type 2 diabetes, obesity, PCOS, Cushing's Disease, and hypothyroidism. In some cases, AN is inherited. Certain medications such as oral contraceptives and large doses of niacin (vitamin B3) can be a cause. Rarely, acanthosis nigricans is associated with certain types of cancer, usually a gastric adenocarcinoma.

1. Why he is treating insulin resistance without diabetes so aggressively and 2. If you were that insulin resistant you wouldn't have been able to lose weight so easily that the doctor commented it was too fast. I would make sure the doctor explains to you what he is treating and why. I would absolutely want clarification (by A1C test) as to whether you have diabetes.

I’ve done a lot of research online and when I read about insulin resistance, it seems to pinpoint nearly everything I’m experiencing. I’m not overweight, and I think that doctors tend to think you have to be overweight to have an issue (at least my current doctor does). I’m paranoid about becoming overweight and have always monitored calories, macronutrients, etc.

If you are type 2, insulin resistance is considered key part of the problem (though insulin resistance can also happening in Type 1). To address insulin resistance you can:- 1. Lose excess weight if you are overweight 2. Adopt a low carb or even a ketogenic diet (be sure to get enough protein and don't overdo the fats) 3. Regular vigorous physical exercise 4. Insulin sensitizing drug such as metformin.

You need to have both your fasting insulin and fasting glucose (sugar) tested. Once you have both blood tests you can calculate your HOMA. Your HOMA will tell you whether you are insulin resistant or not. The formula is on the website I've provided. IR is a PREDICTOR of SVR. Being insulin resistant impairs your ability to achieve a sustained response to Chemotherapy drugs peginterferon and ribavirin... HCV slowly damages the mitochondria through a process of oxidative stress.

Normally there are no antibodies to insulin. If you have IgG and IgM antibodies against insulin, your body reacts as if the insulin is foreign. This may make insulin less effective, or neutralize it. Normal values are 5-20 mcU/mL while fasting; values may differ per laboratory. Check your lab results paperwork for the exact ranges. As far as daily testing, it's to early to tell until the doctor exams your test results. Good luck and let us know everything goes.

IR or insulin resistance is a sign of type 2 diabetes or pre-diabetes. I am assuming you are referring to either the A1C or fasting blood glucose levels. The first thing of course is a change in life style. This does not mean you have to stop eating everything but to be more judicious in your eating habits. In addition, regular exercise is paramount in reducing those :numbers". Talk this over with your physician and get started on these changes.

yes, Insulin resistance means there ends up being too much sugr in yur blood and ergo too much uinsulin, and the insulin cancels out the efficacy of the Interferon causing less than optimal VL responses. People with high IR clear later, and SVR far less frequently. "CoWriter" has also compiled a list along with commentary here: http://www.medhelp.org/user_journals/index/568322?

t lose weight when I was hyperthyroid due to insulin resistance. I already had insulin resistance and this condition worsened to pre diabetes once I was hyperthyroid. I only started to lose weight since reversing my insulin resistance.

Although insulin levels were never extraordinarily high, the increase between the 2nd and 3rd hours seems to be abnormal and indicative of delayed insulin response, a pattern associated with insulin resistance. Several years ago I had elevated cortisol throughout the day. Last year, is was below range for most of the day. It seems to have flip flopped, while DHEA has stayed consistently borderline high (but still in range) and testosterone is elevated.

m so glad you are trying to clean yourself up, but do see a doctor on being insulin resistant. I almost died because of this. Insulin resistance is nothing to take for granted. Please seek medical advice, and keep up the great work for trying to clean up.

I read somewhere that fenofibrates reduce insulin resistance or increase insulin sensitivity. Is that what I am seeing ? Does anyone else have a similar experience ? Thanks.

SOCS-3 elevation causes insulin resistance in the liver. And insulin resistance causes hyperinsulinemia....and high levels of insulin make interferon ineffective Lack of SOCS3 in the liver promotes systemic insulin resistance by mimicking chronic inflammation. We knew all that.

In summary, hepatitis C promotes insulin resistance and INSULIN RESISTANCE INDUCES INTERFERON RESISTANCE, steatosis and fibrosis progression. http://www.ncbi.nlm.nih.gov/pubmed/17131467?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum "Other measures can be taken to enhance svr probabilities in the the face of negative predictors." Like what?

That is totally within the normal range! Even if your doctor anticipates you having insulin resistance and proceeding to develop diabetes you aren't there yet. It would be much more appropriate to recommend a combination of diet for weight loss, cutting carbs and exercise. I'm going to research Insulin Resistance to see if I'm missing something, but that is what I'm seeing now. You need to ask your doctor to explain his treatment and what he is seeing in your medical picture.

This is the classic type of PCOS and by far the most common. High insulin and leptin impede ovulation and stimulate the ovaries to make testosterone. Insulin resistance is caused by sugar, smoking, trans fat, and environmental toxins. Is this you? You have been told that you are borderline diabetic, or you had an abnormal glucose tolerance test. You probably have elevated insulin, and you may also have elevated LH (luteinizing hormone).

My cellular thyroid resistance symptoms have improved since reversing insulin resistance and reducing visceral fat (still have a way to go getting rid of all that stubborn internal fat!).

s a constant struggle, but we must keep exercising, as it protects our bones, strngthens our heart, aids in digestion, and improves insulin resistance. So even if no weight loss is happening, its still helping our body.

Is there a test that can be done to determine whether or not you are insulin resistant? Can you have insulin resistance alone, and not have PCOS or diabetes or anything else? What does Metformin do (is it to combat insulin resistance)? Once on Metformin, can you eventually stop taking it once your hormones and weight and everything are under control, or will your body go back to being out of whack? I didn't really get the opporunity to ask my Dr.

In studying the insulin resistance of 29 people with Hepatitis C, Australian researchers have confirmed that they have high insulin resistance, a precursor to diabetes. However, almost all insulin resistance was in muscle, with little or none in the liver, a very surprising finding given that Hepatitis C is a liver disease. Insulin, a hormone made by the pancreas, helps the body use glucose for energy. The two most important organs that respond to insulin are the liver and muscle.

Niacin and insulin resistance

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