neupogen prescribing information

According to Pegasys prescribing information, a dose reduction of interferon is suggested for moderate to severe neutopenia. A reduction to 135ug/ml is recommended for an ANC less than .75. Discontinuation is recommended for an ANC less than .50. The other option is to administer neupogen which will boost the ANC/WBC. This is the route that my doctor suggested and it helped to avoid a dose reduction.

I have found a paper that is very relevant to your question, as well as the information sheet for Neupogen. I have attached the link below.

however, most sophisticated hematologists/hepatologists will allow their patients to drop to about 500 before either dose reducing or prescribing G-CSF drugs such as Neupogen. Some docs will allow their patients to drop to .30-.35 before they intervene. The obvious choice is to use the Neupogen; continuing on full-dose interferon is the best way to ensure that you eventually achieve SVR.

Damn cj, your doctor should have been proactive and ordered the Neup because the helper drugs are there so we don't have to skip shots. That really and truly erks me. I don't know what your ANC is but you really shouldn't miss shots and I surely do hope you ride that doctors a-s-s until he prescribes the Neupogen. If your ANC hasn't rebounded after tomorrow's test you won't be able to take your shot on Friday.

Do any of you have information about any long term side effects if you had Neupogen for 40 weeks?

Hi, We are going to move this back to HepC so you can get some more information regarding your results. Also, we are forwarding this on to our engineers to see how we can get this adapted for you. Thanks!

This shows the dosing information for neupogen while on hcv tx. According to this information the neupogen should be stopped or taken less often if the anc is over 1000. Mine was at 6500 after five injections, and my doc tells me to keep taking the neupogen. Granulocyte Stimulating Colony Factor Criteria for Use for Hepatitis C Treatment-Related Neutropenia VHA Pharmacy Benefits Management Strategic Healthcare Group and Medical Advisory Panel Prepared by: K. Tortorice, PharmD BCPS , H.

Since I was a Geno 1a and only on Inf/Riba (48 wks), I was very reluctant to do any dose reductions. My gastro doc agreed, so neupogen allowed me to continue from wk 8 until eot with any dose reductions. I agree with the others, that this would concern me, especially being cirrhotic. You want to give yourself the best chance possible.

I started Neupogen about midway (week 12) when my ANC hit .350. I did 4 weekly shots of the prefilled 300s. Weekly CBCs showed that the levels went way up quickly, but also fell off quickly. I'd hit 1.800-2.100, but then be back below .500 on the cusp of the next shot. So, we switched to twice-weekly shots of half doses. Instead of factory-filled 300s, my provider compounding pharmacy makes up 150s and I pick those up, three at a time.

The Hematologist said he was going to start him on Neupogen is anyone else taking this and is it working for them. He also said that he may need a transfusion , which is freaking my husband out because that is how we suspect he contracted the Hep c orignally (back in the 80s). I told him that they screen the blood much differently now then they did back then , but he is still freaking out. Anyone who is taling Neupogen please let me know if it is helping.

I’m not sure that prescribing Neupogen prophilactically will help; have you consulted with a hematologist yet? If not, that might be a good move; what have your doctors recommended so far? Best of luck to you… it sounds like your name-sake is upholding it’s reputation, :o).

no but i did start with very low reds and i am just about ok , well not really but not on rescue drugs anyway

Hi fullmoon1, Your trial will likely have a protocol cutoff for your hgb (hemoglobin) or ANC or whatever blood component they're monitoring - my trial monitored lymphocytes - and when it drops below that, it's a dosage reduction and / or if the trial allows, a rescue drug. The level a trial uses is generally higher than if you were in general treatment. There isn't much choice in this, a trial protocol is a trial protocol.

Neupogen is a new med for him, also Procrit is another new med for him. Obviously I have gotten some spellings incorrect. What I want to do is look up these meds and make a document for him that is easier to read regarding side effects, etc. But, this is not possible until I find someone who knows how to spell these meds, and/or maybe knows something about their side effects personally. Would someone out there please help me with this?

Does your trial give your doctor leeway to determine what comes first, the neupogen or the dosage reduction? If yes, you can ask your doctor to go with the neupogen first, stating you don't want a dosage reduction. Adherence to dosages in the first 12 weeks are particularly important. If the trial does not allow your doctor that leeway and it strictly requires dosage reduction at 750 ANC and neupogen at 500 ANC, you'll have to follow trial mandates.

After my first injection and at my first appt after that injection, my PA said my labs were really crazy and gave me an injection of Neupogen and a prescription for it. I have only 9 shots left and have been taking the Neupogen 3 times a week for the entire tx. They almost took me to 4 times a week. Even with 3 weekly injections of Neopogen my WBC and ANC's are still low. I guess without the Neupogen they would be non-existent.

Neupogen prescribing information

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