lovenox and mthfr

t completely convinced it is anything to worry about but did say we could do Lovenox after I find out I am pregnant (please LORD!) if we wanted to go that route. I need some information and some stories (ood or bad) about MTHFR, what meds you used, what worked, what didn't...anything you got! :) Thanks girls. We will be trying again next month so I want to have all the information before making a decision. :) SSBD to all!

Hello Tif, I have the MTHFR Compound mutation of C677T and A1298C. I am on 30mgs Lovenox twice a day, baby aspirin and 5mg Folic Acid prenatal along with B complex vitamin 100mgs. I have had a sensitive stomach for years having had a ulcer from taking anti-inflammatory (NSAIDS) over the many past years. Aspirin is hard on the stomach as it does the same thing as NSAIDs - irritate the stomach.

I'm really sorry for your loss. Does the dr think you have a blood clotting issue that contributed to the loss? Lovenox is typically used when women have blood clotting antibodies or gene mutations that potentially cause blood clotting such as MTHFR. Also, if you do have these issues, wouldn't you start the lovenox and aspirin while trying to conceive so you don't potentially lose the baby before 7 weeks?

Now I have gotten a surprise BFP and my doc is talking about Lovenox (low dose). Maternal fetal medicine says NO WAY its too risky without having a diagnosed blood clotting disorder, but my OB and RE are willing to put me on it. I'm concerned about the risks (to myself, I know it won't affect the baby). Is it all that risky? Could it help in my situation? I dont know what else to do but really want to have more kids!

and yes, it is an acutal blood clotting disorder, which is why lovenox and/or 81 mgs of aspirin is a must. the reason why mthfr causes miscarrage is tiny blood clots get caught in the placenta, which causes the flow of oxygen to get cut off from the fetus thus the pregnancy ends. if you get this disorder you should not ever take birth control again, because bc increases the chance for blood clots. bc with this disorder can be deadly.

Essentially what this means is that the genes that instruct MTHFR to convert homocysteine to Methionine are mutated and may not be capable of doing this important function. MTHFR is an enzyme that converts Homocysteine to an essential amino acid (Methionine). When the genes are mutated you may be lacking this enzyme. Your Homocysteine levels can possibly climb making the blood clot. Some doctors don't check for the MTHFR mutations and rely only on homocysteine levels.

t require Lovenox, but as far as I am concerned any person with a MTHFR diagnosis should automatically be put on Lovenox and only after a detailed placental scan ultrasound to check and ensure there are no clots present can perhaps be taken off of Lovenox. Some doctors feel the same way, many don't. It's up to you to make sure you voice your opinion regarding the situation, bring documentation and stay strong when it comes to your body, your wants and pregnancy.

I was just wondering if any of you also have this. I have MTHFR C677t and A1298C it is genetic. After my mc they did blood work and found that I have this. My dr was nice, she did all this test after my 1st, she said most drs do it after two or three. I am Diatx and the Prenatal pills and once I get pregnant baby asprin. Just wondering if anyone had this also and your stories. Thank you!

Yes, I am on Lovenox!!!! and I am 33 weeks pregnant...I am also on extra Folic Acid and I was diagnosed with MTHFR...so it does work.... Good Luck to you!!!

MTHFR mutations, C677T and A1298C information found give pretty much the same explanation; forums understandably give the best outcomes and successes. But, would like to know the other side of the coin as well. Birth defects, what kind, has anyone out here had negative outcomes with these pregnancies?

I was positive for MTHFR (i believe heterozygous) and was told to start a Rx prenatal vit with increased folic acid, plus 2 folic acid supplements, and asa81 mg. ANnnnnnnd if i was to become pregnant, i would be on lovenox inj. I have read mixed reviews about this "disorder". My question is, does this really affect pregnancy?Are there studies correllating it with higher incidence of miscarriage? and do folic acids reallyy help?

Has anyone had a successful pregnancy having severe endo and homozygous for MTHFR C677T? I had a miscarriage (first pregnancy) at week 10 last month. I was on baby asprin and Folgard 2.2 pre-pregnancy. I started on Lovenox at week 4 of prenancy and Prometrium weeks 6-10. I've had 2 Laperoscopies for the endo. Been seeing a fertility doc for 2 years - trying to get pregers for 5 years. I'm worried I will have more M/C. Just need to know pregers is possible.

My 3 children who were successful pregnancies have all been diagnosed as Autistic and I am trying to find a link between MTHFR and Autism. If you look hard enough on the web, you will find that both MTHFR and Autism require certain vitamins and diets that are identical. This makes me wonder. Please anyone who joins and has similar experiences in regards to this topic...post, post, post.

After finding out about MTHFR and 3 consecutive losses, I had been sent to two MTHFR specialists here in Toronto and also a high risk perinatal OB/Gyn who have me on 40mg Lovenox and LD (81mg) baby aspirin along with the increased Folic Acid and Vitamin B complex BUT - I just read that taking any form or Aspirin can be responsible for boys having problems with low sperm count along with undescended testes.

after my 5th I had more tests and was diagnosed with MTHFR. My dr ask me to take 1mg folic acid and baby aspirin daily. I asked him for prescription for Folgrad RX. When I get pregnant he will give me levonox or heparin. I hope it will work....

The cardiologist put me on 5mg of folic acid and said that after I became pregnant he would put me on Lovenox from weeks 4-6 until about week 36 and would then switch me to Heparin. He also said that if I went on any type of blood thinners or anti-coagulants while TTC that an egg would not be able to implant - which seems in line with another post that I read in this forum - really not sure where he got this?

Hi everyone, I thought I would start off by introducing myself and my genetic mutation variant C677T. While C677T is one of the two common MTHFR variants it is the most problematic of the variants because of its relationship to clotting and the blood disorder Antiphospholipid syndrome (Factor V Leiden). I was tested recently and was diagnosed with one copy of the variant C677T and I am currently being tested for Factor V Leiden. The other common variant is called A1298C.

i have mthfr and when i was ttc and during my last pregnancy i took lovenox injections. my last pregnancy ended in miscarriage, just like my other 3. however, they think it was due to my progesterone not being high enough. we've decided that we dont want to try to have children now. hope things work out for you!

I tested positive for one copy of the C677T mutation and one copy of the A1298C mutation or Methylenetetrahydrofolate reductase (MTHFR), with hyperhomocysteinemia. Can anyone explain this in Laymens' terms? We know have been referred to a genetic counselor, for what exactly I am not sure. For my next round though, my ER wants to start me on Lovenox. We are still waiting for our chromosome tests results, and should know those by Thursday...

I also have a clotting disorder (compound heterozygous MTHFR). Mine is not so severe that I need blood thinners but I have heard of people on them and they do seem to work well. Were you on them with your other children? My understanding of blood clotting disorders is that you were born with them. Maybe you won't need to take the blood thinners if you never had to take them before. Good luck!

I also have hetero MTHFR and I tested pos for that after 2nd m/c. I take a prenatal, b6, folic (800mcg) and a baby asprin everyday, at the same time, 10 am. I had my third m/c last august but I wonder if I m/c because I hadn't been taking my asprin because I ran out and DH and I weren't trying to conceive at the time so I didn't rush to get more, then I found out I was pregnant and rushed right out to buy some but lost that pregnancy at 6 weeks also.

To get extra Folic acid you should eat eggs, dark leafy vegetables, such as spinach and broccoli, oranges and orange juice and legumes, peas and dried beans. Talk to your doctor and see what would be best for you!

I was recently told I have a vitamin K deficiency and suggested that once a FET is successful with the first beta results, I would need to be on a blood thinner more agressive than the baby aspirin regimn prescribed last time which was successful until week 6 when I miscarried... I'm nervous about taking a blood thinner- seems more risky than need... any thoughts would be greatly appreciated!

Lovenox and mthfr

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