I have been on statins for quite a few years, with problems. First was Lipitor, it did great for my cholesterol, but I started getting skin whelps on my arms. I quit taking it, and within 2 weeks they were gone, despite an allergist not finding it. I tried Vytorin, had muscle and joint pain. But in the past few years, taking simvistatin and a few others, it has been a mood/anger issue. My wife complains, telling me I'm pain to live with, I argue all the time, go off at the slightest thing.