Hi I have had severe Hives for 2 mos. This is the worse outbreak I've ever had, and my last case of Hives was 9 yrs ago. I was in the ER 2x this past month, put on IV steroids, antihistamines & Ranitidine. I had extensive blood work done for a multitude of alleries- all negative, Lupus, Lympoma, Lymes disease, CAT scan, all negative. I've done 2 rounds of Presnisone (which helped greatly), but 2 days after the last Prednisone pill- boom the hives came back bad.