Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested.
The followings are extracts from the label information for Tenofovir:
2.3 Dose Adjustment for Renal Impairment in Adults
Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
Dilantin,carbamezapine,valproate can be used in temporal lobe seizures.Topamax,keppra,lamotrigine can be used as add on drugs with medications mentioned above.Dilantin doesn’t cause depression but can cause decrease in renal function,headache,dizziness,confusion,double vision etc.It is best to discuss your concerns with your doctor before initiation of an alternative antiepileptic drug. Do keep us posted.
Regards!
So after staying overnight and at the vet the next day he came home and has been on Keppra and phenobarbital. 500mg 2x a day Keppra and 60mg 2x a day pheno. He has the side effects which are lessening but hasn't been as bad as I read could be. He is very responsive and is pretty much himself besides the side effects(weak legs, tired). It's been 6 days and no seizures so far. Will be going to vet in a week for check up and blood test again. I am so on edge..
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
I also take Keppra but have never had any problems at all. I suffered with depression for 11 years and came of the medicine fully just before I went on Keppra, and yes I have days where I do feel depressed but with any illness you do have days where you feel depressed even suicidal. So my advice is don't necessarily put it down to Keppra. Talk to the doctor who prescribed Keppra to you and see if you can be referred to a Psychiatrist to talk it through and find out if it is the tablets!
I have no health insurance. I was finally got a really basic coverage, but it doesn't cover keppra. i've been taking keppra for a 2 months. I was switched to phenobarbitol for when I run out. since keppra is not on the charity's formulary.
I hope to God that I cant find some source of keppra before I run out. The phenobarb is scary.
So I'm excited about the links here:
http://brain.hastypastry.net/forums/index.php
http://www.needymeds.
As my DD is in Keppra, and has previously been on other seizure meds, the Keppra, by far has had the least amount of side-effects. You could ask if some of her mood changes, memory loss, etc. are from the stroke vs. the Keppra. Please do not wean her off the medication without a Dr's directive... that could cause withdrawal seizures.
My thoughts are with you that your mother gets well soon.
Did you start it after or before keppra? How long were you on Keppra? I wish my daughter could take Lamictal but her rash got the doctor worried, even though it was ringworm. Have you heard of any other anti-seizure meds that might actually work well for moods? I know Lamictal is a very good mood stabilizer. Good luck.
04/12 changed him to Dilatan and keppra more seizures. 05/12 put back on keppra only 3,500 mg. 06/12 seizures moved to keppra 4,000 mg a day! He has had only 1 seizures since been on 4,000, but this is a very high dosage. He is going to see an seizures specialist. Hoping he can get this dosage down.
ve responded very well to medications like Neurontin, Lyrica and Topamax. Keppra is another one that has been recommended to me. The key really is finding which side effects are the best to deal with. It's really an individual thing. I couldn't handle the weight gain, tiredness and bloating that I felt while on Lyrica, although it helped me immensely with pain. Lyrica is an anti-seizure medication too.
I read something on rxlist about moodswings and irritibility related to Keppra. It's believed that Keppra makes your brain "dump" Vitamin B6 at times which lowers dopamine or seratonin levels and makes you feel horrible.
Does your daughter take vitamins? I'd try some Vitamin B6 if her multivitamin doesn't contain it. I started taking Trader Joe's High Potency vitamins and feel much, much better since starting.
Good luck.
Continued with Keppra and Di Tan Tang 2X/day each for another 8 days. Then took her Keppra down to 1/day for 2 weeks. Then she went one day with no Keppra and the next day she had a seizure. This seizure was longer, but her disorientation was shorter. Vet then said to go back to giving her Keppra for 30 days and we will re-evaluate. So for the next 30 days she was taking Keppra 1/day and Di Tan Tang 2/day.
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
How much Keppra do you take, and how long did it take before you seizures completely stopped?
Thank you for reading!
I am on the off brand of keppra and I was wondering if anyone uses adderal to help with the side effects of this medication. I find myself to be out of it most days and not have a drive to do anything.
Anyone else on Keppra to prevent myoclonic jerks (JME diagnosed)? I am, and have been on Keppra for almost 5 years. Started at age 23 and I am now 28. At the beginning they made me very sluggish, but after about 2 months I felt wonderful (since it was the first time in my life I wasn't having seizures!!
its been 8 months since my mothers TBI- she had a seizure yesterday-she has been off keppra for 1 1/2 months-the side effects of keppra are aweful-they ask her questions and wonder why she is out of it and doesn't know her last name-(after they gave her keppra in the hospital) what can she take that is less evasive to her health and recovery??
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