However, if the patient remains symptomatic after 4 weeks, therapy with
itraconazole, 200 mg daily for 6 to 12 weeks, can be given. Patients who have severe outbreak-associated histoplasmosis and all immunosuppressed patients should be treated. Initial therapy with amphotericin B, 0.7 to 1 mg/kg daily, can be followed by oral itraconazole after a favorable response is noted. Antifungal therapy should be given to all patients with chronic pulmonary histoplasmosis.