Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg. Thus the combination of 30fold higher approved dose and the double micromolar inhibition potency makes, in theory, irbesartan 60 fold more potent to inhibit Hbv entry.
m currently taking Irbesartan every morning and is now controlled well. I enjoy traveling in hot conditions, some days can be up to 39 degrees. Can my blood pressure medication stand such heat if I was to say just put it in my wallet? I'm always traveling to different places and don't always have access to a fridge or ice to take on hand. If not, are there any other heat resistance BP medication i can try?
These drugs, already on the market for treating hypertension, have been shown to stabilize and in many cases (like mine) reduce aortic root diameters, depending on the dosage you take. The studies generally indicate that the higher the dosage (at least maximum FDA-approved dosage or higher), the better the results. Sufficient dosage is key; if you don't take enough of the drug, you will get no results.
Can you please advise if I am taking high blood pressure medication (irbesartan) and Altorvastatin for high cholesteron and I am also taking Tamoxafin for breast cancer (about to come off this drug), is it adviseable to take Leptin Cocoa for health weight loss or would this affect the medications?
put me on lowest dose of Losartan and I got joint pain in my thumbs and then in a knee so I weaned myself off but my BP was very high (systolic) during visit. He puts me on Irbesartan, SAME class of drug, then goes on VACATION. It's the smallest dose and I took a corner of a pill yesterday, no pill today, BP is fine, I'm in PAIN. My thumbs hurt, my right foot and left knee, I don't feel well and then I read that all of this are side effects of this drug.
They routinely prescribe beta blockers for patients with aortic root dilatation, even though the most recent studies have shown that they DO NOT HELP YOU. Beta blockers are prescribed because they make sense on paper, but in practice, they are absolutely useless.
These doctors are also grossly behind the times. I don't know whether they are ignorant of the latest, big-news breakthroughs or just unwilling to try them.
I am a male 70 years of age. I have been on 150mg Irbesartan and 5mg Amlodipine daily since October 2010. This controlled by BP within acceptable limits. Since late April, however, the systolic has risen to an average of around 150. My doctor wants me to add a beta blocker to the other medications. Since last October my heart rate was averaging below 60. Since late April it is averaging around 70.
my friend just started taking trandolapril 1mg and Irbesartan its only been a couple days but she feels awful
dizzy, heart palpatations, head ache and her blood pressure is still really high 190/110
should she just stick it out?
The medication prescribed to me is Avapro HCT 150mg/12.5mg (Irbesartan and hydrochlorothiazide) taken once daily (1 tablet) mainly to help ensure the blood pressure remains under 140 systolic, which is believed to help reduce the pressure on the aorta and root. I am booked in for a second opinion with another cardiologist next week mainly to re-assure myself and my wife (and kids) that things are chugging along okay.
Hi, My doctor has diagnosed a mild calcification of the aortic valve and mild to moderate aortic regurgitation. I also have mild hypertension which is controlled with Irbesartan. I'm 50 and don't seem to have any symptoms but what can I expect and what can I do to improve my condition.
Call your pharmacist or your doctor and ask if this is a known side effect of the med you're on. Ask if stopping has any risks, and if not, it's a good idea to stop and see if that solves your problem. Sometimes you have to taper off some meds but unless your BP is so high you're about to drop dead from it, most BP problems depending on your age and how long the problem has existed can be fixed by changing diet and lifestyle.
Hello Chiari world!
I was diagnosed with Chiari in May. Now two of my cousins, my mom and brother have all be diagnosed with it as well. We are joining a genetics study and are curious if any of you others out there have joined any studies. We would like to know what the Pro's and Con's were/are. We feel that since so many of us have been diagnosed in the last three months that our family may be able to help future families and our future generations by joining the study.
I was wondering if anyone knows of any free syringoma studies being conducted in southern california. Your help is greatly appreciated.
It remains unclear whether hepatitis B virus (HBV) genotype has an influence on treatment response -- as is the case for hepatitis C virus (HCV) -- due to inconsistencies across studies and failure to account for differences in race/ethnicity, according to a report in the March 2010 Journal of Hepatology.
It is well known that viral genotype has a major impact on response to interferon-based therapy for hepatitis C, but it is unclear whether this is also true for hepatitis B.
I have been recently working on some clinical studies on anxiety and I was wondering if anybody knew of any clinical support services? I have looked into a few and came across some that sound pretty good. I was wondering if anybody has ever worked with TransPerfect Trial Interactive before? I checked out their website, TrialInteractive, and they seem pretty solid but I would like to hear other people's take on it. What do you guys think? or does anybody have any other suggestions?
Hi, I'm in Knoxville Tn, and I'm looking for information on the trail studies for Hep C treatment for my mom. Does anyone have any suggestions on where to start?
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