Ezetimibe was found to have a 50%inhibition conc of 25micromolar, while irbesartan, a commonly used angiotensin inhibitor to reduce blood pressure, was found to inhibit at 11.9 micromolar. Both compounds have similar MW, but irbesartan is given at up to 300mg per day, while exetimibe is dosed at 10mg. Thus the combination of 30fold higher approved dose and the double micromolar inhibition potency makes, in theory, irbesartan 60 fold more potent to inhibit Hbv entry.
Can you please advise if I am taking high blood pressure medication (irbesartan) and Altorvastatin for high cholesteron and I am also taking Tamoxafin for breast cancer (about to come off this drug), is it adviseable to take Leptin Cocoa for health weight loss or would this affect the medications?
put me on lowest dose of Losartan and I got joint pain in my thumbs and then in a knee so I weaned myself off but my BP was very high (systolic) during visit. He puts me on Irbesartan, SAME class of drug, then goes on VACATION. It's the smallest dose and I took a corner of a pill yesterday, no pill today, BP is fine, I'm in PAIN. My thumbs hurt, my right foot and left knee, I don't feel well and then I read that all of this are side effects of this drug.
m currently taking Irbesartan every morning and is now controlled well. I enjoy traveling in hot conditions, some days can be up to 39 degrees. Can my blood pressure medication stand such heat if I was to say just put it in my wallet? I'm always traveling to different places and don't always have access to a fridge or ice to take on hand. If not, are there any other heat resistance BP medication i can try?
Call your pharmacist or your doctor and ask if this is a known side effect of the med you're on. Ask if stopping has any risks, and if not, it's a good idea to stop and see if that solves your problem. Sometimes you have to taper off some meds but unless your BP is so high you're about to drop dead from it, most BP problems depending on your age and how long the problem has existed can be fixed by changing diet and lifestyle.
I am a male 70 years of age. I have been on 150mg Irbesartan and 5mg Amlodipine daily since October 2010. This controlled by BP within acceptable limits. Since late April, however, the systolic has risen to an average of around 150. My doctor wants me to add a beta blocker to the other medications. Since last October my heart rate was averaging below 60. Since late April it is averaging around 70.
my friend just started taking trandolapril 1mg and Irbesartan its only been a couple days but she feels awful
dizzy, heart palpatations, head ache and her blood pressure is still really high 190/110
should she just stick it out?
Hi, My doctor has diagnosed a mild calcification of the aortic valve and mild to moderate aortic regurgitation. I also have mild hypertension which is controlled with Irbesartan. I'm 50 and don't seem to have any symptoms but what can I expect and what can I do to improve my condition.
The medication prescribed to me is Avapro HCT 150mg/12.5mg (Irbesartan and hydrochlorothiazide) taken once daily (1 tablet) mainly to help ensure the blood pressure remains under 140 systolic, which is believed to help reduce the pressure on the aorta and root. I am booked in for a second opinion with another cardiologist next week mainly to re-assure myself and my wife (and kids) that things are chugging along okay.
You can add a low dose sartan (arb) or ace inhibitor drug (i.e. 75 mg Irbesartan) once daily and this has been proven to promote regression of hypertrophy and improve DD. Coq10 has as well, along with both reducing ventricular arrythmia risks. Something to think about when you see your doctor. Arb drugs have no side effects for the vast majority of patients <95%.
Good to know at least we can share a similar experience. We're not alone and we can support each other!
1 mm/yr, though some do grow rapidly which is why they need to be monitored. Drug therapy also seems to be able to slow the growth (beta blockers, irbesartan, losartan). The fact that the arch and the thoracic aorta aren't involved means that should surgery become necessary, it will be considerably less complex and risky. I had surgery in 2004 at age 46 for a 5.0 cm aneurysm of the ascending aorta and today I lead a totally normal, active life.
THIS is the problem with most cardiologists today. They routinely prescribe beta blockers for patients with aortic root dilatation, even though the most recent studies have shown that they DO NOT HELP YOU. Beta blockers are prescribed because they make sense on paper, but in practice, they are absolutely useless.
These doctors are also grossly behind the times. I don't know whether they are ignorant of the latest, big-news breakthroughs or just unwilling to try them.
Hi, my question is regarding an intrathecal drug pump and drug testing. The short story is that I've had 21 back surgeries, and after being on many (just about most) pain meds, my doctor finally put in a drug pump with dilaudid. As most probably know, this pump is installed in the abdomen with a catheter that runs to my back and is inserted into the intrathecal space of the spine (where the spinal fluid is). So the medication does not go into my blood stream or cross the blood brain barrier.
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