imatinib gvhd

Eithne01, The treatment of chronic myeloid leukemia (CML) has changed significantly since the late 1990s, with the development and subsequent approval by the Food and Drug Administration of imatinib (in 2001), the first of a class of medications called tyrosine kinase inhibitors, which target the specific abnormality that causes CML. Before that time, patients were treated with other therapy, including interferon and bone marrow transplant, and had very poor outcomes.

It is possible that the white blood cell count would normalize after 2 weeks of taking Imatinib (Gleevec). Most responses to Imatinib are rapid since it targets the molecular pathogenetic event in CML. You may seek a second opinion if that will give you a peace of mind. Good luck.

lots of people die all the time because they reject traditional treatments and go with 'natural' things instead I would think of using alternatives along with regular treatments, but not in place of them. Some alternative things might have some benefit. Isn't homeopathy the approach where you dilute some substance down to one part per billion or so, and then expect it to actually have some curing power?

Are you currently on any medication like imatinib? The neutropenia can be due to your current medication. You can ask your hematologist for G-CSF injection if you have persistent neutropenia. Patients with CML are immunocompromised and can easily acquire infections. Neutropenia also puts a patient in an immunocompromised state. For now, it is very important to prevent acquiring any infection. You should avoid crowded places and persons with ongoing infection. Good luck.

Hi. Chronic Myelogenous Leukemia (CML) is a blood disorder caused by an acquired genetic defect in the pleripotent stem cell. It has several phases: indolent chronic or stable phase, aggressive or advanced phase, and accelerated and blastic phase. The transition between phases may take years (on the average, 4 to 6 years from the stable phase to aggressive phase).

s sister comes out does her part, Don receives the transplant and is put on all the ordinary protocol drugs for GVHD and about a week after transplant he has a neurological allergic reaction to prograph. He was totally wacked out, hallucinations, jabbering, restless just a real nutcase, then he becomes nonresponsive to anyone and his breathing very irratically. They ship him to ICU where he codes and they put him in a coma and on a ventilator. This was on a Saturday.

Average survival rates are generalizations, not applicable to a particular patient. The prognosis is relatively good. Newer techniques are being tried, including imatinib and stem cell transplantation. All the best, and God Bless!

Hey I had a bone marrow transplant two years ago and, on my doctor just told me that he will put me on steroids because my liver enzymes have been elevated and I just didn't take it very well. I am scared and I know there is nothing I can do to prevent stupid GVHD. I am so scared to start taking these drugs. Please help !!

GVHD was ruled out as the rash or fever did not persist...it was more of a febrile rash...my only point is even if there is a minor chance of infection...do i need to test further or the tests that i have done by far are enough? I understand that i may be wasting your time...

TY for the reply. Yes I was told and am thinking that its parasitc or allergy. I went to aruba in June but that wouldn't have an affect on me now, would it?

Therapy with corticosteroids is used for the treatment of most and additional therapy is available and dependent upon the type of HS. Newer medicines such as imatinib and mepolizumab are said to be promising. So, should your son have HS, there is reason to be optimistic regarding a positive response to currently available therapy. You should request, of his doctor, an additional explanation for the tentative diagnosis of pre-hypertension. Good luck.

This is to prevent a complication called graft-versus-host disease (GVHD). In GVHD, some of the donated blood cells (the lymphocytes) attack the patient's body. GVHD after a blood transfusion is rare but can be very serious. (GVHD is also a possible complication of a bone marrow or cord blood transplant using donated cells.) -gotta admit, that last part is sobering. However seems very rare but still, considering his treatment, at least something to be aware of.

Patients with hypereosinophilic syndrome should be tested for the presence of the FIP1L1-PDGRFA-mutatition in order to identify patients that could benefit from a treatment with a tyrosine kinase inhibitor such as Imatinib. At present, immunosuppression is still the treatment of first choice for Churg-Strauss syndrome. Novel treatment modalities for both diseases include immunomodulation with interferon alpha and biologics such as antibodies against interleukin 5.

I was prescribed high doses of prednisone to tread Graph vs. Host disease (GVHD) and as a result have had to endure complete joint replacements. Right knee and left hip have been replaced, the other two are in the planning. I've been on pain medication for about 8 yrs. for one reason or another. I've been prescribed; Dilaudid, Methadone, Oxycodone, MsContin, Fentanyl and have weaned off, and back on, about 4 times in the course of 8 yrs.

PET CT SCAN mentioned no metabolically alive cells, As precaution I was put on Imatinib for last 4 months. LFT was normal for first 3 months, This month I have raised SGOT & SGPT LEVELS & also HBV Ag is positive ( Was Negative in test done before my Surgery).Should I continue on Imatinib or need to go for a second opinion. What is the course duration & Will this HBV ben cured.

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