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The last thing anybody would want is to stop the Gleevec, which is a wonder drug of anti-cancer treatment. So we must think of "managing" the hyponatremia problem.
I haven't found anything about long term use of Gleevec. But what springs to mind is that she might have started some other drug recently, which is turning mild hyponatremia to severe hyponatremia. Even ibuprofen. Has she?
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I wonder if at the heart of it, this is a political issue and has anything to do with the Orphan Drug laws. Before these laws were in place, drugs were often not developed for conditions that occurred relatively low in the population, due to low profitability for the drug companies. As I understand it, under the Orphan Drug laws, these companies are now eligible for incentives to develop drugs which might not otherwise be developed.
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
Arrowhead’s candidate for AAT deficiency has been designated as an orphan drug. Had you done that with previous candidates?
CA: This is the first time for us, and it’s important. This is a clear orphan population; it’s thought there’s about 100,000 potential patients in the U.S., and a similar portion in Europe. Orphan designation is going to help us not only with speed to approval, hopefully, but also will help us with communication to the FDA.
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
* buprenorphine Metabolized into norbuprenorphine by cytochrome-P450 isoenzyme 3A4
* Tyrosine kinase inhibitors, including Gleevec and Tasigna, used to treat chronic myelogenous leukemia and gastrointestinal tumors.
Infectious myocarditis is relatively rare, and it is very startling when it occurs, maybe especially in young people (but older folks are pretty darned shocked, too). Each case is individual, and unfortunately we are only patients like you--not doctors. You simply must write down your questions and concerns in an organized way and *ask* your doctors, who know your history and have examined and treated you, about this. Keep at them until you get answers that mostly satisfy you.
We are looking forward to further investigate this novel drug for treatment of the most severe viral hepatitis,” said Heiner Wedemeyer, MD, Professor at Hannover Medical School and Chairman of MYR`s Clinical Advisory Board. “Myrcludex B has shown biological activity in the previuos trials and has the potential to become a new option for these difficult-to-treat patients.
Now her wbc is 58 and her hometown doctor is putting her back on Hydrea. Her family is concerned she is going to take a serious chemo drug when there is still a question of what she has. Could it be an infection that isn't showing up? Should she be put on antibiotics to see if that cures any underlying infection? Should they do more tests of any kind that you can suggest? She is JAK2 negative and PH negative also thus the atypical diagnosis.
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