Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
However when i moved from Atlanta they insisted on a bone biopsy that said no to Mastocytosis. All my Atlanta drs said Mastocytosis explained everything including my reoccurring pericarditis. So if its not Mastocytosis, what is it. They offered nothing here in Chattanooga, so I dont know what is wrong with me.
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
dear doctor, can you please tell where we can treat Mastocytosis, the baby was born with it and it's 2 months old now, he was born with swollen liver and spleen and he was treated only after a month with antihistamine, we are in Macedonia.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
She stated that non sclerotic may suggest that the lesions were not benign and is sending her to a pediatric orthopedic doctor. My daughter has a history of systemic mastocytosis that affects her skin and presents with hives. She has not had an episode in over a year and is other wise healthy. Her growth is on track and she doesn't consistantly complain of pain in this region.
m too young to have all these problems I asked my new Dermotolgist about Mastocytosis. Did a biopsy of rash on belly.Still waiting for results. He said it may or may not be Mastocytosis but I definitely have too much histamine. I'm up to 4-10mg of Atarax a day so I can function again. Still having flares on 3 so we'll add a pill a week until we find the right dosage. So my question is what else could cause too much histamine and all those problems.
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
Mpox is not only transmitted by touching, but is also transmitted by respiratory droplets. If the children in your life are immunocompromised, wearing a mask would help.
Have you googled symptoms of mpox? You can avoid contact with anyone who has a rash, but people are contagious 1-4 days prior to symptoms.
Honestly, I'm not sure why you've latched onto mpox.
My daughter has Mastocytosis, was a hair stylist for over 20 years, all the chemicals she breathed in has caused her to be allergic to almost everything.
If you breathe it...you eat it.. it's in your body.
i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
I have no idea how your question has come to be on the Mastocytosis Board but, I'm not sure if you have something serious or not. Contact your doctor and go in and get a check-up and let her/him know what is going on and see what their thoughts are. Good luck!
Hello,
I have seen an allergist and blood tests came back negative for allergies. He suspects urticaria pigmentosa/mastocytosis. I don't feel I have the intense itching that is described....but some of my other symptoms seem to fit mastocytosis. I am waiting on the skin biopsy results to see if that is the diagnosis. This is not encouraging to me. I really was hoping for a food allergy...something I can intentionally avoid.
Malignancies either associated with or thought to be associated with activated tyrosine kinase enzymes include hypereosinophilic syndrome, systemic mastocytosis, chronic myelomonocytic leukaemia and dermatofibrosarcoma protuberans.
Hope this helps. Please let me know if there is any thing else and do keep me posted. Take care!
I take Hemocyte-plus for anemia and Synthroid for hypothyroidism. I have recently been diagnosed with systemic mastocytosis. I have many other symptoms as well, so I'm not saying that this is what you probably have, but in trying to get diagnosed, I was tested by an endocrinologist first. Your endocrinologist may find some things that could lead to a proper diagnosis.
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