Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
so i will know about this tonight when someone calls me about his appointment today, i believe he is starting a drug called Gleevec today also, i guess dr has some samples in his office but told him this drug cost 2,000 a month...he has no insurance..
well he lives in northern ca, and im out here in fl...
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
Myelosuppression with neutropenia (decrease in neutrophils) and thrombocytopenia (decrease in platelet count) can be a side effect of treatment. Usually, discontinuation of drug intake is advised until the blood counts increase. You should have your white blood cell count repeated after 1-2 weeks and see if it already improves. You should report to your doctor if you experience any symptoms like fever.
http://www.medhelp.org/forums/show/61 or the expert forum at: http://www.medhelp.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
i was diagnosed with cml in march of 2009 and was also taking 150mg of elavil at bedtime to control migraines for like 10 years. then this past dec. a heart test showed i had prolonged qt of the heart so i was stopped 'cold turkey' by a dr and its been down hill ever since. i have had the shakes, loss of appetite and constant nausea. i wake up evey morning shaky really bad.
I should mention that I have CML but it has been in remission for the last two years and I am no longer taking Gleevec.
I am scheduled to be looked at by a group that kills the nerve endings in the heart that causes AF but there is an 18 month waiting period.
My question is how many times can I be cardioverted and what is the downside of having it so often?
* buprenorphine Metabolized into norbuprenorphine by cytochrome-P450 isoenzyme 3A4
* Tyrosine kinase inhibitors, including Gleevec and Tasigna, used to treat chronic myelogenous leukemia and gastrointestinal tumors.
My mother was diagnosed with atypical CML in April by her hometown doctor. She then went to Mayo and the doctor there told her she did not have Leukemia based on her blood work there, but she had been overdosed on Hydrea during the summer to the point her wbc was 3 and was only recovered to 11 by the time of her appt in Sept. Now her wbc is 58 and her hometown doctor is putting her back on Hydrea.
In their report, the researchers also discuss the compassionate use of Gleevec in one young neurofibromatosis patient with an airway-compressing plexiform neurofibroma. This patient was not considered an ideal candidate for surgery given the location of the tumor and its vascular nature. A three month administration of the drug was effective in significantly shrinking the tumor without any observed side effects.
term=cmml
I see different drugs in the pipeline, including Gleevec which is very successful in other blood cancers. I do see some monoclonal antibodies there. Aha, the bortezomib study is here:
http://clinicaltrials.gov/ct2/show/NCT00437086
But it was just a pilot, i.e., the very earliest stage of investigation. But that apparently showed it to be safe, as expected. IOW, it is not a risky last-chance drug. Neither most likely are none the MABs risky, they are very mild in side effects.
Is anyone else on here suffering with depression or anxiety in their pregnancy?
I was diagnosed with PND after having my LG and got rid of it fine but have been living with anxiety ever since, I was coping with it fine but since falling pregnant this time my anxiety had definitely worsened and finding the right treatment is tricky.
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