Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Three years ago I was diagnosed with Polycythemia vera after having a headachces for weeks. I was stabilized using Hydroxyurea which I take everyday.
I am now happily married and would like to have a family with my husband. I was wondering if my menstral issues could have been impacted by Polycythemia vera?
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
I too do not have prostate cancer but, was diagnosed with polycythemia vera and am taking Hydroxyurea as a long lifetime treatment. I also have a significant amount of hairloss. Is there anything we can do to save our hair? I also would like to impose the question of prognosis for polycythemia vera. None of the doctors are willing to state or predict life expectancy, I only know what I've read on the internet. Thank you for answering our questions.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
Hi,
Thanks for your advise!
I forgot to mention background of the disease.
He was diagnosed with "Essential thrombocytosis" 4 years back and was prescribed hydroxyurea (also known as hydroxycarbamide) for reduction of the platelet count to the normal range.
Frequency of hydroxyurea (500 mg) usage - one tablet on one day and two tablet on next day.
Doctor said he got above transferred onto Leukemia.
About his health condition - he had no complications from Diabetes.
In the treatment of Longitudinal Melanonychia the hyperpigmentation of the skin and nails induced by medication such as doxorubicin, cyclophosphamide and hydroxyurea can be reversed back to normal. Treatment may depend on the underlying cause. Longitudinal Melanonychia needs to be evaluated by biopsy to corroborate if it is benign finding rather than a sign of subungual melanoma.
Take care and keep us posted.
i get my heart checked every 2 weeks now and i am fine with the qt thing. i take the chemo pill called gleevec and have to force myself to eat so i dont get sick when i take it. how long will these withdrawel problems go on? i have xanax to take (1mg) but dont work to good. i should would appreciate any advice from any one on how to deal with these issues, family dr says its anxiety but i think its the withdrawels from the high dose of elavil.
It is safe with tolerable side effects which include edema, skin rash, fatigue, and myelosuppression. Other treatment options include hydroxyurea, interferon alpha, and stem cell transplantation.
The advanced phase and the blastic phase can be worrisome, but can still be treated.
At this point, it is very important that she regularly follows-up with her hematologist. There will be series of blood examinations to check how she responds to the medicine she is taking.
Good luck.
I should mention that I have CML but it has been in remission for the last two years and I am no longer taking Gleevec.
I am scheduled to be looked at by a group that kills the nerve endings in the heart that causes AF but there is an 18 month waiting period.
My question is how many times can I be cardioverted and what is the downside of having it so often?
There are medicines (like Hydroxyurea) that really help people with sickle cell disease. Sorry for the confusion.
I have a oncologist who treats my blood disease and he told me that the itching is a symptom of this disease and we have tried so many medication for this itching and one of them is Hydroxyurea . I am taking it .It helps some but you have to be careful with it and under doctor's care to check your blood cells because it can lower your blood cells. I go for blood work every month. I am getting panic attacks and get very upset when I know I have to take a shower and cry sometimes.
* buprenorphine Metabolized into norbuprenorphine by cytochrome-P450 isoenzyme 3A4
* Tyrosine kinase inhibitors, including Gleevec and Tasigna, used to treat chronic myelogenous leukemia and gastrointestinal tumors.
There is no genetic basis for the CML therefore she was not put on Gleevec. She is on Hydrea to keep the wbc count down to a more normal level. I think the only thing that led to the CML diagnosis was the extremely high wbc with no sign of infection or other cancer. Mayo did the same blood tests as the hometown doctor, as well as the lab in Iowa City. I would like them to run other tests but havent a clue what to ask for.
Attempted to moisten skin (neutral soap/hydroxyurea cream). After one month, lesions on elbows had resolved, but barely could celebrate and they had spread to the entire body - back and lower back, above pubic bone, internal thighs, and only one front tibial surface (had a rupture of the ACL/meniscus early March - same leg), neck, face (eyelids mainly) and back of knees.
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