Hi there.
It is important to be empathic, and let your brother know that you are always there for him. However, you should not overdo this, since this might lower your brother's self esteem further and cause him to have self-pity. CML is a manageable disease given the appropriate medications. Not all CML's are candidate for Gleevec. Only those who tested positive for the philadelphia chromosome or the bcr-abl gene would be candidates to receive gleevec.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
Hi.
Response to imatinib (gleevec) can be dramatic just like what you experienced. Myelosuppression with neutropenia (decrease in neutrophils) and thrombocytopenia (decrease in platelet count) can be a side effect of treatment. Usually, discontinuation of drug intake is advised until the blood counts increase. You should have your white blood cell count repeated after 1-2 weeks and see if it already improves. You should report to your doctor if you experience any symptoms like fever.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
worth of atypical dysplastic nevi when my first and only early melanoma appeared. I go every 6 mos for checkups and check my back every time of the month as a reminder to look in the mirror! I have no familial connection to melanoma and the Dr's are amazed given the extensive am't of dysplastic nevi I have all over. My Melanoma was removed '07 and all clear since then.
Early detection is key.
Hello, I had a suspicious mole on my neck removed in June and it came back as mild-moderate dysplastic nevus with differential diagnosis of early melanoma in-situ. The area was re-excised with 3mm margins. Since then I have had the slides re-evaluated by UPenn Dermatopathology and their diagnosis was Severe dysplastic nevus with differential diagnosis of evolving melanoma in-situ.
Hi
The presence of abnormal cells (dysplasia) in a mole on biopsy indicates that there is a high risk (more than double) for development of a melanoma. The entire mole and a margin of normal tissue around it need to be removed. Usually once a mole has been removed, chances of recurrence are minimal.
Melanoma is the most serious type of skin cancer which can spread to several parts of the body and leads to the greatest number of deaths.
2- Would having the area of the skin where the mole was, as well as the surrounding skin area as well, biopsied (or analyzed for traces of melanoma cells) be a viable option to definitively know if this was malignant melanoma?
3- If I had a chunk of skin removed where the mole used to be (as explained in #2), would that cause a functional or cosmetic deformity to my finger? The mole was on the middle joint of my middle finger, near the joint.
I appreciate you taking the time to read my post.
i was diagnosed with cml in march of 2009 and was also taking 150mg of elavil at bedtime to control migraines for like 10 years. then this past dec. a heart test showed i had prolonged qt of the heart so i was stopped 'cold turkey' by a dr and its been down hill ever since. i have had the shakes, loss of appetite and constant nausea. i wake up evey morning shaky really bad.
I checked the official prescribing information for Veramyst (fluticasone nasal spray) and it does not specifically state that this drug is contraindicated for those with melanoma or any other cancer. However, for those with recent nasal surgery, this drug should be avoided as it delays wound healing and increases the risk of fungal (Candida) infection. If your melanoma surgery was near your nasal area, this may be one reason why your doctor refused to prescribe the drug to you.
Most remain stable over time. Researchers estimate that the chance of melanoma is about ten times greater for someone with more than five dysplastic nevi than for someone who has none, and the more dysplastic nevi a person has, the greater the chance of developing melanoma.
http://www.cancer.gov/cancertopics/factsheet/Risk/moles
The risk is much more in families with melanomas and dysplastic nevus syndrome FAMM Syndrome.
In a 10-year retrospective study, Marghoob et al.
I had a mole removed from my back and my results came back as mild atypical for melanoma. For now it was begnign. My question is am I now predisposed for this type of cancer? Is my risk higher than someone who has not had this type of a mole? How common is this? And what are the chances this mole could grow back as a melanoma? I am very scared. Am I overreacting?
I got diagnosed in Febuary of this year with a cataract, my optomitrist refered me to a specialist, and when I went to see him in November, there was a tumor within my eye, and subsequent retnal tearing. He booked me in for immediate surgery as he said it was eye melanoma. My surgery is in about 2 weeks. My question is; would my untreated cataract for at least 1 year cause, or attribute to me getting eye melanoma?
Now I am terrified that it was a melanoma and I have scrapped it off and the cancer will start growing without me knowing. Can you scrap off a melanoma? If it was a melanoma will the pigmentation grow to the surface again? Does melanoma heal? I know if I go to the gp they will not refer me to a dermatologist and can not afford to pay privately.
Just scared and it wont go awayy.. has been there for 2+yrs. Any recommendations?? Or help to take it off .
I have been looked over by 4 separate Dermatologists every 3 months for the last year and a half. I even had my Melanoma scar biopsied again for recurrence (negative).
My Oncologist is pushing me to get a PET scan done. Now, I'm all for having a PET scan done if there is a high risk of cancer. All the tests I have had done have been extremely positive though.
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