I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
Hi there.
It is important to be empathic, and let your brother know that you are always there for him. However, you should not overdo this, since this might lower your brother's self esteem further and cause him to have self-pity. CML is a manageable disease given the appropriate medications. Not all CML's are candidate for Gleevec. Only those who tested positive for the philadelphia chromosome or the bcr-abl gene would be candidates to receive gleevec.
I am a leukemia survivor. I have developed dry dark patches on my back. What caused it? What's the best treatment?
There is no genetic basis for the CML therefore she was not put on Gleevec. She is on Hydrea to keep the wbc count down to a more normal level. I think the only thing that led to the CML diagnosis was the extremely high wbc with no sign of infection or other cancer. Mayo did the same blood tests as the hometown doctor, as well as the lab in Iowa City. I would like them to run other tests but havent a clue what to ask for.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Hi.
Response to imatinib (gleevec) can be dramatic just like what you experienced. Myelosuppression with neutropenia (decrease in neutrophils) and thrombocytopenia (decrease in platelet count) can be a side effect of treatment. Usually, discontinuation of drug intake is advised until the blood counts increase. You should have your white blood cell count repeated after 1-2 weeks and see if it already improves. You should report to your doctor if you experience any symptoms like fever.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
* buprenorphine Metabolized into norbuprenorphine by cytochrome-P450 isoenzyme 3A4
* Tyrosine kinase inhibitors, including Gleevec and Tasigna, used to treat chronic myelogenous leukemia and gastrointestinal tumors.
I was told a year ago I had low platelets and I'm just now going back 2 days from now. I'm worried about Leukemia. I've heard from various sources the prognosis for untreated acute leukemia is 3-6 months. Is it possible I could've survived without any treatment for 12-15 months? Please limit your answers to involve acute leukemia. I'm aware chronic leukemia could still be a possibility.
I heard recently on a tv show that there are blood tests that will confirm whether you are likely to get leukemia. Both my parents died of leukemia in 2009. My father had AML, my mother had CML. Can anyone give me some information I am seeking?
I was asked to have a blood test taken in 2009, and my doctor then said there was something they would watch, but then she retired, and I have no idea what she was talking about.
Any info would be a benefit! Thank you!
i was diagnosed with cml in march of 2009 and was also taking 150mg of elavil at bedtime to control migraines for like 10 years. then this past dec. a heart test showed i had prolonged qt of the heart so i was stopped 'cold turkey' by a dr and its been down hill ever since. i have had the shakes, loss of appetite and constant nausea. i wake up evey morning shaky really bad.
She's in hospital getting chemotherapy for acute leukemia. Ironic because she's always resisted treatment due to side effects. Just wondering out loud if long term HCV has role in her new illness. If you PM me I'll give contact info on FB.
Let me start by saying that I have CML which is Chronic Myelogenous Leukemia, and I had no symptoms. I went for a routine blood test, and my Leukemia showed in the blood work with a high White Blood Count, and then we went from there.
If you would post a little bit more information, I might be able to ease your mind or direct you in the right direction.
Her inclination was toward leukemia but which type so we were to do the marrow biopsy.That day she ran bloodwork again. She found wbc improved significantly yet still showed anemia in blood work. Said bone marrow test not needed. I have been weak and ill for so long and in lots of pain. Dr. Said this could be anemia. I think the dr. Is wonderful and I will take her advice and suppl. Iron and eat better. We re test bllod in 3 mos.
Mocha is exactly right, slightly low might be normal for some people. It would be unreasonable to think of leukemia. You can worry if your platelets decline steadily, or if you had a reading under 50. Under 25 would usually be very concerning.
Side fact: My father had platelets measured at 5 (yes, five) from lymphoma, yet there was no bleeding.
Is leukemia a possibility if I've been having chronic wrist pain since mid-January 2008. I went to the dr., he did an xray and said nothing appeared. I had a CBC w/differential done Dec 31 2007 and everything turned up normal.
I know bone/joint pain is a symptom of leukemia, would this be more systematic or could it be a localized area?
I also came down with a cold a few days ago, constant coughing, mucous but no fever, please any insights?
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