You might find he starts to be able to tolerate the pill. Gleevec is first choice for treating CML, and if he is doing good in every other way then encourage him that he is doing great.
I hope this helps you. I would be glad to help you with any other questions.
Hi, I don't know the answer -- but since both CML and Gleevec toxicity produce anemia because of marrow suppression, maybe it's not possible to tell the difference. E.g., both would show a low reticulocyte count.
This full text paper on anemia from Gleevec https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.23879 shows that other signs such as red blood cell size can vary, so that doesn't seem to help. Sorry.
Is it possible that after taking gleevec for only two weeks WBC droped from 36.7 to 7? All other blood counts are also came back to normal range. Could doctor make mistake in diagnosis of CML? Maybe I should get seg second opinion?
I was diagnosed with CML and given Gleevec 400 ml. After taking gleevec for 2 weeks doctor took additional blood test. My WBC dropped from 36.5 to 7.1 and all other blood counts came down to normal range. I'm wondering if gleevec could give such fast hematological response or I was possibly misdiagnosed originally. I don't and didn't have any symptoms, my spleen and liver weren't enlarged, no enlarged lymph. Should I get second opinion asap? Please, help me.
After two weeks on 400mlg gleevec my WBC droped from 36.5 to 7.1. My doctor told to come for additional test in two weeks. Now my WBC is 1.3 and absolute neutrophils count is 0.04. I was told to stay home on antibiotics. How long it may take for my counts to clime back to safe range. And of course, I'm off gleevec right now. Does it seem that dose of 400mlg is too high for me.
Am on Gleevec 400mg, now having problems with blisters on the palm. What can I do about it?
I was diagnosed last year and was immediatley put on gleevec 400mg/day.At my last consult my metabolic stats had risen,hence blood tests to determine if the gleevec is no longer working.I am still in firstphase and wonder what my options are if the gleevec is no longer an option.Amin pretty good form,just very tired and a lot of bone pain.
I have CML and was treated with Gleevec for 4 years and achieved remission. I have for the past several months been experiencing sudden onset of weakness which last for hours, to days. My blood pressure which has remained under control for several years with atenolol has been running 145/105 and higher for the past three to four months. I have a feeling of fullness in my stomach, and I have sporatic episodes of mild coughing, this occurs maybe once a week.
From what you have posted, at this point there is possibly only a suspicion that there might be CLL. The most important thing for now is to know the "absolute number of lymphocytes". On the CBC report, this would be a line that says something like:
- lymphocytes abs
or
- lymphs #
(The line that says % doesn't matter.)
Usually, a doctor wants to see a high absolute number of lymphocytes for 3 months before becoming too concerned.
It has been 15 mos since I was diagnosed w/CLL. In that time I have experienced occassional left arm tremors, for example, if I hold my cell phone in my left hand to dial or text I experience a tremor.
In addition, I have had attacks of cellitutis, is that related to the CLL??
My husban is two years out on his bone marrow transplant, he had stage 4 non hodgins lymphoma, they call it cll. The Dr said he is doing good in remission , but, Gary is TIRED all the time, his back itches , he is loosing weight because he isn't 'hungry, he almost passes out when he exert himself. He has a caugh too. he is getting the night sweats again sometimes not all the time. We don't know what to think ...when the Dr. say yes your fine...your blood work it good. help please...
Question concerns Merkel Cell Carcinoma and CLL. Patient is 63 yo male, dx'd with prostate cancer '95 and treated with seeds. PCa metastatic to bone in '99. PCa controlled with double dose Casodex. Patient dx'd with CLL '99-no treatment given. WBC mostly 35-45K asymptomatic except slow wound healing. Patient dx'd with Merkel Cell Carcinoma '07. Merkel cell treated unsuccessfully with chemo and successfully with radiation.
s team studied blood samples provided by 45 CLL patients up to six years before they knew their CLL diagnosis. The researchers ran two different tests on the blood samples, looking for monoclonal B cells.
All but one of the patients had monoclonal B cells in their pre-CLL blood samples, and 41 out of 45 had monoclonal B cells show up on both blood tests -- so monoclonal B cells could be a marker of future CLL."
Note that is about CLL, not AML or CML.
My father has had CLL for many years and now my doctor is doing final blood test to confirm the disease and a CAT Scan. Since my father has this and now I do (I am 59 yrs) does this mean CLL is hereditary.
I was sort of taken by surprise, I thought my white cell count was off because I was under stress with a husband who has terminal bladder cancer and I have been tired and stressed.
Does this disease always progress slowly or does it depend on each person?
Hi, unfortunately with smudge cells and your other signs, the first thing to look into is CLL and other B-cell blood cancers. The high calcium suggests Multiple Myeloma, but then CLL can also cause high calcium.
It's important to remember that CLL usually has a very good survival rate.
You don't mention easy bruising, so maybe the marrow is still okay.
If your WBC and your number of smudge cells hasn't been rising, that should probably be a good sign.
Good luck to you.
I was just diagnosed with CLL atypical. I am a 48 yr old, white female. I have heard that CLL atypical has a tendency to progress quicker or be more aggressive. I am in stage 1 (on 0-4 scale). I would appreciate any information that anyone can give.
I was diagnosed with CLL at 48 and am now 53. Have been in watch and wait mode these years....and my counts have been growing slowly and no concerns so far. At my last lab work though, my lymphocytes jumped from 74% of my wbc to 85%....a significant jump from all these years of creeping growth. I'm quite concerned.....I am not currently sick or fighting any infections......am I now at the point where I can expect things to start going downhill?
I am a Vietnam veteran and was diagnosed with CLL in 1994 (There has already been an Agent Orange/CLL connection made). I began suffering various skin cancers a couple of years before and have been through many mohs surgeries. My oncologists agrees that CLL and Skin cancers are most probably related to my exposure to Agent Orange during my tour in Vietnam.
FYI! I was also diagnosed with Crohns disease in 1985 and suffered a severe bout of Shingles (hospitalized) in 1999.
I was diagnosed with CLL about five years ago and have had no treatment yet. My most recent blood work showed the following "high" levels:
WBC - 74.7
RBC - 6.13
HGB - 16.6
HCT - 52.1
RDW - 20.4
Lymph% - 86.1
Gran # - 9.0
Lymph # - 64.3
Baso # - .5
The one "low" count was Gran % at 12.0
I have no idea what any of this means. My hematologist tells me that we're still in a "wait and watch" stage, as I get more and more fatigued and am constantly sweating.
Recommended
